中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (3): 41-45.

• 研究论文 • 上一篇    下一篇

聚氧乙烯醚溶致液晶对胆固醇的增溶作用

戴乐蓉, 杨庆平, 吴佩强   

  1. 北京大学物理化学研究所 北京 100871
  • 收稿日期:1995-09-26 修回日期:1995-12-31 出版日期:1996-06-10 发布日期:1996-06-10
  • 基金资助:
    国家攀登计划资助项目

Solubilization of Cholesterol in Polyoxyethylene Ether Lyotropic Liquid Crystal

Dai Lerong, Yang Qingping, Wu Peiqiang   

  1. Institute of Physical Chemistry, Peking University, Beijing 100871
  • Received:1995-09-26 Revised:1995-12-31 Published:1996-06-10 Online:1996-06-10

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摘要： 研究了 C12(EO)4-H2O 及 C12(EO)4-卵磷脂-H2O 体系的液晶行为和胆固醇在液晶相中的增溶作用.C12(EO)4-卵磷脂-H2O 体系增溶胆固醇的行为与卵磷脂-H2O 体系类似.C12(EO)4-H2O 体系增溶胆固醇后,液晶组成中 C12(EO)4的浓度范围更宽.X 射线衍射结果表明,C12(EO)4-H2O 层状液晶相中增溶胆固醇后,两亲双分子层厚度 d0增加,分子排列更紧密,水对两亲分子层的渗透作用降低.

关键词: 聚氧乙烯醚, 溶致液晶, 胆固醇, 增溶

Abstract: Phase behaviour and solubilization of cholesterol in liquid crystal phase of C12 (EO)4-H2O system and C12(EO)4-lecithin-H2O system were investigated.The phase diagram of C12(EO)4-lecithin-water-cholesterol system was similar to lecithin-water-cholesterol system.In C12(EO)4-H2O ststem,where cholesterol was solubilized,the concentration range of C12(EO)4 in liquid crystal was broader than that without cholesterol.The results of X-ray diffraction showed that,when cholesterol was solubilized into C12(EO)4-H2O lamellar liquid crystal,the thickness of amphiphile bilayer d0 increased,the amphiphile molecular array was more compact and the penetration of water molecules decreased.

Key words: polyoxyethylene ether, lyotropie liquid erystal, eholesterol, solubilization

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