应用化学 ›› 1996, Vol. 0 ›› Issue (2): 7-10.

• 研究论文 • 上一篇    下一篇

LiCl/DMAc溶剂体系中长链脂肪酸纤维素酯的制备及其药物释放性能

胡运华, 卓仁禧   

  1. 武汉大学化学系 武汉 430072
  • 收稿日期:1995-06-09 修回日期:1995-12-27 出版日期:1996-04-10 发布日期:1996-04-10
  • 基金资助:
    国家自然科学基金

Preparation of Long-Chain Fatty Acid Esters of Cellulose in LiCl/DMAc System and Their Drug Release Properties

Hu Yunhua, Zhuo Renxi   

  1. Department of Chemistry, Wuhan University, Wuhan 430072
  • Received:1995-06-09 Revised:1995-12-27 Published:1996-04-10 Online:1996-04-10

摘要: 在LiCl/DMAc溶剂体系中由纤维素与长链脂肪酸酰氯反应制备长链脂肪酸纤维素酯,并研究了反应条件对酯化反应取代度的影响。结果表明在适当的反应条件下,酯化取代度可达到2.85(95%).还研究了纤维素酯作为药物控制释放载体对LNG、Aspirin、BSA的释放性能。

关键词: 纤维素, 酯化反应, LiCl/DMAc, 控制释放

Abstract: Long-chain fatty acid esters of cellulose were prepared by the reaction of cellulose with acid chlorides in LiCl/DMAc solution.The effects of reaction conditions on the degree of substitution were studied.The results showed that the degree of substitution could reach 2.85 under proper reaction conditions. The drug release properties from these cellulose ester matrixes were also investigated.

Key words: cellulose, esterification, LiCl/DMAc, controlled drug release