中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (1): 116-118.

• 研究简报 • 上一篇    

微量热法研究Schiff碱药物的抗菌作用

冯英1, 刘义1, 谢昌礼1, 屈松生1, 乐芝凤2, 冯长建2, 沈昊宇2, 张香才2   

  1. 1. 武汉大学化学系 武汉 430072;
    2. 华中师范大学化学系 武汉
  • 收稿日期:1995-06-09 修回日期:1995-09-25 出版日期:1996-02-10 发布日期:1996-02-10
  • 基金资助:
    国家自然科学基金

Studies on Antibacterial Activity of Schiff Base Metal Complexes Using Microcalorimetric Method

Feng Ying1, Liu Yi1, Xie Changli1, Qu Songsheng1, Luo Zhifeng2, Feng Changjian2, Shen Haoyu2, Zhang Xangcai2   

  1. 1. Department of Chemistry, Wuhan University, Wuhan 430072;
    2. Department of Chemistry, Central China Normal University, Wuhan
  • Received:1995-06-09 Revised:1995-09-25 Published:1996-02-10 Online:1996-02-10

PDF

322

被引次数

5

摘要： Schiff碱及其金属配合物具有抗病毒抗菌等生物活性[1-3].可采用试管法和平板计数法来进行抗菌活性研究[3,4].

关键词: Schiff碱药物, 微量热法, 产气杆菌

Abstract: The thermograms of Aerobacter aerogenes in solutions with different concentrations of Schiff base metal complexes have been determined by use of the LKB-2277 Bioactivity Monitor.The experimental results show that the sequence of antiaerobacter aerogenes activity of Schiff base metal complexes is:Co(Ⅲ)-2,4-L>Zn-2,4-L>2,4-L>Fe(Ⅲ)-2, 4-L>Cu(Ⅲ)-2,4-L(2,4-L:2,4-dihydroxybenzaldehyde glucosamine Schiff bases).Their half inhibitory concentrations also increase with this sequence.

Key words: Schiff base, microcalorimetry, aerobacter aerogenes

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