中华医学超声杂志

应用化学 ›› 1992, Vol. 0 ›› Issue (6): 57-60.

• 研究简报 • 上一篇    下一篇

四氯合铂(Ⅳ)类配合物的合成表征及其抗癌作用

邵伟平1, 管荫桐1, 唐雯霞1, 藉秀娟2   

  1. 1. 南京大学配位化学研究所, 南京 210008;
    2. 中国医学科学院药物研究所, 北京
  • 收稿日期:1991-12-23 修回日期:1992-05-18 出版日期:1992-12-10 发布日期:1992-12-10

SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIⅥTY OF TETRAPLATINUM(Ⅳ) ANALOGUE COMPLEXES

Shao Weiping1, Guan Yintong1, Tang Wenxia1, Ji Xiujuan2   

  1. 1. Institute of Coordination Chemistry, Nanjing University, Nanjing 210008;
    2. Institute of Materia Medica, Chinese Academy of Medical Science, Beijing
  • Received:1991-12-23 Revised:1992-05-18 Published:1992-12-10 Online:1992-12-10

PDF

313

被引次数

2

摘要： 顺铂作为第一代无机抗癌药物已被广泛使用,但副作用较大。碳铂是第二代无机抗癌药物,虽肾毒性和肠胃道反应比顺铂低,但在某些肿瘤治疗方面,活性低于顺铂。最近,Aderson等发现tetraplatin(tetrachloro(d,1-trans)1,2-dimino cyclohexane platinum (Ⅳ))对L1210白血病比顺铂有更好的疗效,并有广谱的抗癌活性,较高的水溶性和较低的毒性,尤其是对L1210白血病延命率>300%,对P388白血病延命率>98%[1]。本文报道5种新的四氯合铂(Ⅳ)类配合物的合成,表征及其抗癌作用。

关键词: 抗癌活性, 四氯合铂化合物, S-180肉瘤

Abstract: Five tetraplatinum (Ⅳ)analogue complexes were synthesized and characterized, The antitumour activity of the synthesized complexes against S-180 in mice and their water and ethylacetate solubilities were determined, The complex of was found to have a higher activity, The relationship between the activity of the complexes and their water and ethylacetate solubilities, the mechanism of the action of Pt (Ⅳ)complexes were discussed.

Key words: antitumor activity, tetraplatinum (Ⅳ) complex, S-180 sarcoma

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