应用化学 ›› 1992, Vol. 0 ›› Issue (4): 35-40.

• 研究论文 • 上一篇    下一篇

2-氯苯甲酰基苯基脲系列化合物对昆虫几丁质的抑制作用

陆忠娥1, 孙大庆1, 李凯1, 陈克潜1, 张应阔2, 赵学忠2   

  1. 1. 苏州大学化学系, 苏州 215006
    2. 南京军区军事医学研究所
  • 收稿日期:1991-06-14 修回日期:1991-06-14 出版日期:1992-08-10 发布日期:1992-08-10
  • 基金资助:
    国家自然科学基金

THE INHIBITION EFFECT OF SUBSTITUTED 2-CHLOROBENZOYL PHENYL UREA ON CHINTIN SYNTHESIS

Lu Zhonge1, Sun Daqing1, Li Kai1, Chen Keqian1, Zhang Yingkuo2, Zhao Xuezhong2   

  1. 1. Department of Chemistry, Suzhou University, Suzhou 215006;
    2. Institute of Military Medical Science, Nanjing
  • Received:1991-06-14 Revised:1991-06-14 Published:1992-08-10 Online:1992-08-10

摘要: 本文用二令淡色库蚊(Culex Pipiens Pallens)对2-氯苯甲酰基苯基脲及其硫脲进行定量构效关系的研究,找出合成高效无氟昆虫几丁质抑制剂的结构因素。

关键词: 昆虫几丁质抑制剂, 2-氯苯甲酰基苯基脲, 构效关系

Abstract: The quantitative structure-activity relationships (QSAR) have been studied between larvicidal activity against second instar larvae of Culex Pipiens Pallens and substituted 2-chlorobenzoyl phenyl urea or thiourea. From QSAR study, some important structure factors influencing the larvicidal activity of this series are found. Electronic parameter is the most important factor influencing the lavicidal activity, and some compounds hare the same insecticidal activity as 2,6-difluorobenzoyl-4-chlorophenyl urea(PH6040).

Key words: chintin synthesis inhibitor, chlorobenzoyl (4-substituted phenyl)urea, quantitative structure activity retationships (QSAR)