中华医学超声杂志

应用化学 ›› 1987, Vol. 0 ›› Issue (5): 69-71.

• 研究简报 • 上一篇    下一篇

呋喃西林,呋喃西林类似物及其铜(Ⅱ)、锌(Ⅱ)、镍(Ⅱ)络合物的合成和抑菌作用

房喻1, 孙作民1, 任铸1, 向家兰1, 薛志文2, 李彤2   

  1. 1. 陕西师范大学化学系;
    2. 陕西师范大学生物系
  • 收稿日期:1986-12-29 修回日期:1987-03-17 出版日期:1987-10-10 发布日期:1987-10-10

SYNTHESIS AND BACTERIOSTASIS OF FURANCILIN COMPLEXES WITH COPPER(Ⅱ),ZINC(Ⅱ),AND NICKEL(Ⅱ)

Fang Yu1, Sun Zuomin1, Ren Zhu1, Xiang Jialan1, Xue Zhiwen2, Li Tong2   

  1. 1. Department of Chemistry, Shanxi Normal University;
    2. Department of Biology, Shanxi Normal University
  • Received:1986-12-29 Revised:1987-03-17 Published:1987-10-10 Online:1987-10-10

PDF

370

摘要： 近年来,文献上报导了许多缩氨基脲、缩氨基硫脲及其金属配合物的抗癌、抗微生物活性,发现金属配合物往往比配体表现出更高和更广泛的生物活性。呋喃西林(O2N-C4H2O-CH=NNHCONH2)是一种曾用于临床的硝基呋喃类广谱抗菌药物。但由于副作用大不再用于体内。近年来耐药菌株不断增加以及交叉耐药性的出现,使得治疗耐药菌株感染成为医学上的一大难题。

Abstract: Five complexes [Cu(FDSC)2]Cl2, [Cu(FDTSC)2]Cl2, [Cu(N-FDSC)]Cl2], [Zn(N-FDTSC)2] and [Ni(N-FDTSC)2] have been synthesized and characterized FDSCH=N-(2-furfural)-semicarbazone,FDTSCH=N-(2- furfural)-thiosemicarbazone,N-FDSCH=N-(5-nitro-2 -furfural)-semicarbazone and N-FDTSCH=N-(5-nitro-2-furfural)-thiosemicar-bazone.It is found that N-FDSCH, N-FDTSCH, [Cu(N-FDSC)]Cl2] and [Zn(N-FDTSC)2] showed a significant bacteriostasis on Staphylococcus aureus, Bacillus subtilis and Escherichia Coli.The relationship between the bacteriostatic activity and the structure of the compounds is discussed in the paper.

网站版权 © 应用化学     本网站备案：吉ICP备12000082号