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葡萄糖基N-异丙基丙烯酰胺共聚物合成及其温敏性

娄少峰1,张婳1,张培培1,田利强1,聂华丽1,权静1,2*,朱利民1*   

  1. (东华大学1.化学化工与生物工程学院；2.生态纺织教育部重点实验室 上海 201620)
  • 收稿日期:2012-06-20 修回日期:2012-07-26 出版日期:2013-04-10 发布日期:2013-04-10
  • 通讯作者: 朱利民，教授; Tel/Fax:021-67792655; E-mail:lzhu@dhu.edu.cn; 研究方向：酶化学及缓释材料
  • 基金资助:
    中央高校基本科研业务费专项资金，纤维材料改性国家重点实验室开放课题(LK0908)

Synthesis and Temperature Sensitivity of N-isopropylacryamide Copolymers with Glucose Pendant

LOU Shaofeng1, ZHANG Hua1, ZHANG Peipei1, TIAN Liqiang1, NIE Huali1, QUAN Jing1,2*, ZHU Limin1*   

  1. (1.College of Chemistry,Chemical Engineering and Biotechnology;2.Key Laboratory of Science & 
    Technology of Eco-Textile of Ministry of Education，Donghua University,Shanghai 201620,China)
  • Received:2012-06-20 Revised:2012-07-26 Published:2013-04-10 Online:2013-04-10

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摘要： 采用酶促法合成了可聚合的葡萄糖乙烯酯衍生物6-O-乙烯己二酰-D-葡萄糖(OVAG)，通过自由基聚合法将N-异丙基丙烯酰胺和OVAG共聚，制备出了温敏含糖共聚物poly(OVAG-co-NIPAAm)，通过1H NMR对聚合物的结构进行了表征，用凝胶色谱测定共聚物的相对分子质量。 用可见光吸收法测定了poly(OVAG-co-NIPAAm) 的低临界溶解温度（LCST），动态光散射测定了聚合物在水溶液中的流体力学直径，静态光散射测定了共聚物在水溶液中的均方旋转半径。 结果表明，采用自由基聚合制备的温敏含糖共聚物在水溶液中自组装成近似球形的纳米粒子，其LCST由N-异丙基丙烯酰胺均聚物的32 ℃提高至39 ℃，粒径在60 nm左右，粒径分布较窄。

关键词: 自聚集, 温敏糖聚合物, 酶促合成, 双亲水

Abstract: The polymerisable glucose derivates, 6-O-vinyladipoyl-D-glucose was sythesized by chemoenzymatic transesterification, the novel thermosensitive glycopolymers, poly(N-isopropylacryamide-co-6-O-vinyladipoyl-D-glucose)(NIPAAm-co-OVAG) were fabricated free radical copolymerization from N-isopropylacryamide(NIPAAm) and 6-O-vinyladipoyl-D-glucose(OVAG). The structures and properties of the copolymers were confirmed by 1H NMR, UV-Vis absorbance and GPC. Moreover, the hydrodynamic diameter and gyration radius of the poly(OVAG-co-NIPAAm) in aqueous solution were studied by laser light scattering. Finally, we found that the poly(OVAG-co-NIPAAm) chains exist in aqueous as nearly spherical nanoparticles with diameter around 60 nm and the lower critical solution temperature(LCST) increased from 32 ℃ of PNIPAAm homopolymer to 39 ℃.

Key words: Self-aggregation, thermosensitive glycopolymer, enzyme catalyzed synthesis, double-hydrophilic

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