中华医学超声杂志

应用化学 ›› 2011, Vol. 28 ›› Issue (04): 421-425.DOI: 10.3724/SP.J.1095.2011.00358

• 研究论文 • 上一篇    下一篇

β-环糊精对氯诺昔康的包合作用

王茹林*,姜鸿彦,秦姝竹,王鹏   

  1. (山西医科大学化学教研室 太原 030001)
  • 收稿日期:2010-06-22 修回日期:2010-10-27 出版日期:2011-04-10 发布日期:2011-04-10
  • 通讯作者: 王茹林，教授; Tel/Fax:0351-4135645; E-mail:rulin_wang@yahoo.cn; 研究方向：超分子化学
  • 基金资助:
    山西省科技厅自然科学基金（20051029）资助项目

Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives

WANG Rulin*, JIANG Hongyan, QIN Shuzhu, WANG Peng   

  1. (Chemistry Department of Shanxi Medical University,Taiyuan 030001)
  • Received:2010-06-22 Revised:2010-10-27 Published:2011-04-10 Online:2011-04-10

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摘要：

采用荧光光谱、差热扫描和核磁共振法研究了不同酸度和温度下β-环糊精（β-CD）、羟丙基β-环糊精（HP-β-CD）和磺丁醚β-环糊精（SBE-β-CD）对氯诺昔康（LX）的包合特性。 结果表明，3种环糊精与氯诺昔康均形成1∶1的包合物。 以包合常数作为包合稳定性的量度，包合稳定性为SBE-β-CD＞HP-β-CD＞β-CD。

关键词: 氯诺昔康, β-环糊精, 荧光光谱, 差热扫描, 核磁共振

Abstract:

The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD), hydroxypropyl-β-cyclodextrin(HP-β-CD), and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy, differential scanning calorimetry(DSC) and NMR at different pH and temperature. The results showed that the 1∶1 inclusion compounds were formed between lornoxicam and CDs. Based on the formation constants, the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD＞HP-β-CD＞β-CD.

Key words: β-cyclodextrin, fluorescence spectrometry, DSC, NMR

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