Preparation of Molybdenum Disulfide Nanoparticles and the Cytoprotection on Cardiac Myocytes

doi:10.11944/j.issn.1000-0518.2020.09.200042

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (9): 1010-1021.DOI: 10.11944/j.issn.1000-0518.2020.09.200042

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Preparation of Molybdenum Disulfide Nanoparticles and the Cytoprotection on Cardiac Myocytes

GAO Ming^a, ZHAO Kaidong^b, LIU Xiangyong^c, JIN Yuanzhe^a*

^aThe Fourth Affiliated Hospital of China Medical University,Shenyang 110000,China;
^bThe Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China;
^cCollege of Life Sciences,Qingdao University,Qingdao,Shandong 266071,China

Received:2020-02-17 Published:2020-09-01 Online:2020-09-09
Contact: JIN Yuanzhe, professor; Tel/Fax:024-62043559; E-mail:yzjin@cmu.edu.cn; Research interests:application of nanoparticles in cardiovascular diseases
Supported by:
Supported by the National Natural Science Foundation of China(No.21575071, No.21874079)

Abstract

Abstract: Cardiovascular diseases currently dominate the cause of death worldwide. Oxidative stress injury is one of the important pathogenesis of cardiovascular diseases. The purpose of this study is to investigate the antioxidative protection effect of molybdenum disulfide (MoS₂) nanoparticles on cardiomyocytes under oxidative stress injury. We synthesized MoS₂ nanoparticles with antioxidant-like enzyme activity by a one-step hydrothermal method. MTT, intracellular apoptosis, intracellular reactive oxygen species (ROS) detection, and Western Blot experiments confirm that MoS₂ nanoparticles (100 μg/mL) can protect H9c2 cardiomyocytes from oxidative stress injury induced by hydrogen peroxide (H₂O₂). At the same time, it also promotes the proliferation of H9c2 cardiomyocytes. This study shows that MoS₂ nanoparticles can be used to construct antioxidant defense against cardiovascular diseases caused by oxidative stress injury, and provide experimental data and theoretical basis for the development of nanomedicine in the resistance to myocardial oxidative damage.

Key words: molybdenum disulfide nanoparticles, antioxidant enzyme-like activity, oxidative stress, reactive oxygen species, myocardial protection

GAO Ming, ZHAO Kaidong, LIU Xiangyong, JIN Yuanzhe. Preparation of Molybdenum Disulfide Nanoparticles and the Cytoprotection on Cardiac Myocytes[J]. Chinese Journal of Applied Chemistry, 2020, 37(9): 1010-1021.

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Preparation of Molybdenum Disulfide Nanoparticles and the Cytoprotection on Cardiac Myocytes

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