Recent Progress in the Development of Smart Coatings Based on Antimicrobial Peptides

doi:10.11944/j.issn.1000-0518.2020.08.200145

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (8): 865-876.DOI: 10.11944/j.issn.1000-0518.2020.08.200145

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Recent Progress in the Development of Smart Coatings Based on Antimicrobial Peptides

SUN Zhenlong, YAN Shunjie^*, ZHOU Rongtao, ZHANG Zhenyan, OUYANG Zhaofei, ZHU Xuezhen, YIN Jinghua

National Engineering Laboratory of Medical Implantable Devices,Key Laboratory for Medical Implantable Devices of Shandong Province WEGO Holding Company Limited,Weihai,Shandong 264210,China

Received:2020-05-15 Published:2020-08-01 Online:2020-08-07
Contact: YAN Shunjie, R&D engineer; Tel/Fax:0631-5717897; E-mail:sjyan@weigaogroup.com; Research interests:surface functionalization of biomedical materials
Supported by:
National Key Research and Development Project(No.2017YFC1104800), the National New Material Production and Application Demonstration Platform Project(No.TC90H3ZV), China Postdoctoral Science Foundation(No.2017M621225), the Postdoctoral Innovation Project of Shandong(No.[2019]173), Postdoctoral Project of Weihai(No.[2018]45), and the Chinese Academy of Sciences-WEGO Group Hightech & Development Program(No.2017-2020)

Abstract

Abstract: Antimicrobial peptides (AMP) have been extensively studied due to their rapid-acting, broad-spectrum activities and low possibility to develop resistance to bacteria. A potential approach to combating device-associated infections is to construct AMP-based antibacterial coatings on biomaterial surfaces. However, traditional AMP releasing coatings show temporary action due to the inherently limited reservoirs, while direct surface-tethering of AMP on surface usually suffers from the accumulation of dead microorganisms blocking functional groups. Considering the varied and complex applications of biomaterials, it is highly required to facilely adjust its functions in service and in antibacterial cases. A generic strategy by integrating the stimuli-responsive polymers and the existing antibacterial strategies exhibits a great potential in advancing the clinical applications of the AMP-based smart antibacterial platforms. In this review, the progress in the development of smart coatings based on AMP is reviewed. The main approaches to designing AMP releasing and non-releasing coatings are described, the roles of stimuli-responsive polymers in AMP-based smart coatings are also introduced, and the switching between its functions in service and antibacterial function is discussed. Furthermore, the future development of AMP-based smart coatings are prospected.

Key words: antimicrobial peptide, controlled release, surface immobilization, stimuli responsive, smart antibacterial materials

SUN Zhenlong, YAN Shunjie, ZHOU Rongtao, ZHANG Zhenyan, OUYANG Zhaofei, ZHU Xuezhen, YIN Jinghua. Recent Progress in the Development of Smart Coatings Based on Antimicrobial Peptides[J]. Chinese Journal of Applied Chemistry, 2020, 37(8): 865-876.

References

[1] Campoccia D,Montanaro L,Arciola C R. A Review of the Clinical Implications of Anti-infective Biomaterials and Infection-Resistant Surfaces[J]. Biomaterials,2013,34:8018-8029.
[2] Campoccia D,Montanaro L,Arciola C R. A Review of the Biomaterials Technologies for Infection-Resistant Surfaces[J]. Biomaterials,2013,34:8533-8554.
[3] ZHANG Jianhong,CHEN Jingjie,GAO Lingling,et al. Opportunities and Challenges for Antimicrobial Polymers in the Antibiotic Resistance Crsis[J]. Polym Bull,2019,10:149-162(in Chinese).
张建红,陈婧婕,高玲玲,等. 高分子材料在病菌耐药性危机中的机遇与挑战[J]. 高分子通报,2019,10:149-162.
[4] Zasloff M. Antimicrobial Peptides of Multicellular Organisms[J]. Nature,2002,415(6870):389-395.
[5] ZHOU Xinyu,ZHOU Chuncai. Design, Synthesis and Applications of Antimicrobial Peptides and Antimicrobial Peptide-Mimetic Copolymer[J]. Prog Chem,2018,30(7):913-920(in Chinese).
周欣宇,周春才. 抗菌肽及类抗菌肽的设计、合成及应用[J]. 化学进展,2018,30(7):913-920.
[6] Hancock R E,Sahl H. G. Antimicrobial and Host-defense Peptides as New Anti-infective Therapeutic Strategies[J]. Nat Biotechnol,2006,24(12):1551-1557.
[7] Alves D,Olivia Pereira M. Mini-review:Antimicrobial Peptides and Enzymes as Promising Candidates to Functionalize Biomaterial Surfaces[J]. Biofouling,2014,30(4):483-499.
[8] Sun H,Hong Y,Xi Y,et al. Synthesis, Self-assembly, and Biomedical Applications of Antimicrobial Peptide-Polymer Conjugates[J]. Biomacromolecules,2018,19(6):1701-1720.
[9] Salditt T,Li C,Spaar A. Structure of Antimicrobial Peptides and Lipid Membranes Probed by Interface-Sensitive X-Ray Scattering[J]. Biochim Biophys Acta,2006,1758(9):1483-1498.
[10] Kazemzadeh-Narbat M,Kindrachuk J,Duan K,et al. Antimicrobial Peptides on Calcium Phosphate-Coated Titanium for the Prevention of Implant-Associated Infections[J]. Biomaterials,2010,31(36):9519-26.
[11] Nordstrom R,Malmsten M. Delivery Systems for Antimicrobial Peptides[J]. Adv Colloid Interface Sci,2017,242:17-34.
[12] Cheng H,Yue K,Kazemzadeh-Narbat M,et al. Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis[J]. ACS Appl Mater Interfaces,2017,9(13):11428-11439.
[13] ZHAO Mingqi,HUANG Weipin,HU Mi,et al. Functional-Polymer-Based Coatings for Biomedical Materials' Surface[J]. Mater Rep,2019,33(1):27-39(in Chinese).
赵鸣岐,黄威嫔,胡米,等. 生物医用材料表面高分子基涂层的功能化构筑[J]. 材料导报,2019,33(1):27-39.
[14] Shukla A,Fleming K E,Chuang H F,et al. Controlling the Release of Peptide Antimicrobial Agents from Surfaces[J]. Biomaterials,2010,31(8):2348-2357.
[15] Li B,Jiang B,Boyce B M,et al. Multilayer Polypeptide Nanoscale Coatings Incorporating IL-12 for the Prevention of Biomedical Device-Associated Infections[J]. Biomaterials,2009,30(13):2552-2558.
[16] Costa F,Carvalho I F,Montelaro R C,et al. Covalent Immobilization of Antimicrobial Peptides (AMPs) onto Biomaterial Surfaces[J]. Acta Biomater,2011,7(4):1431-1440.
[17] Onaizi S A,Leong S S. Tethering Antimicrobial Peptides:Current Status and Potential Challenges[J]. Biotechnol Adv,2011,29(1):67-74.
[18] TANG Xin,MAO Xinfang,MA Binyun,et al. Antimicrobial Peptides: Current Status and Future Challenges[J]. China Biotechnol,2019,39(8):86-94(in Chinese).
唐馨,毛新芳,马彬云,等. 抗菌肽的研究现状和挑战[J]. 中国生物工程杂志,2019,39(8):86-94.
[19] Godoy-Gallardo M,Mas-Moruno C,Yu K,et al. Antibacterial Properties of hLf1-11 Peptide onto Titanium Surfaces:A Comparison Study Between Silanization and Surface Initiated Polymerization[J]. Biomacromolecules,2015,16(2):483-496.
[20] Wei T,Yu Q,Chen H. Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way[J]. Adv Healthcare Mater,2019,8:e1801381.
[21] Ding X,Duan S,Ding X,et al. Versatile Antibacterial Materials:An Emerging Arsenal for Combatting Bacterial Pathogens[J]. Adv Funct Mater,2018:1802140.
[22] YU Qian,CHEN Hong. Smart Antibacterial Surfaces with Switchable Function to Kill and Release Bacteria[J]. Acta Polym Sin,2020,51(4):319-325(in Chinese).
于谦,陈红. 具有“杀菌-释菌”功能转换的智能抗菌表面[J]. 高分子学报,2020,51(4):319-325.
[23] Yan S,Luan S,Shi H,et al. Hierarchical Polymer Brushes with Dominant Antibacterial Mechanisms Switching from Bactericidal to Bacteria Repellent[J]. Biomacromolecules,2016,17:1696-1704.
[24] Wei T,Tang Z,Yu Q,et al. Smart Antibacterial Surfaces with Switchable Bacteria-Killing and Bacteria-Releasing Capabilities[J]. ACS Appl Mater Interfaces,2017,9:37511-37523.
[25] CAO Biyu,SUN Xiuhua,GAO Changlu. Research Progress in Antibacterial Materials with Convertible Functions Between Bacteria-Killing and Foul-Releasing[J]. Mod Chem Ind,2019,39:29-32(in Chinese).
曹弼宇,孙秀花,高昌录. 杀菌-防污功能可转换抗菌材料研究进展[J]. 现代化工,2019,39:29-32.
[26] Blum A P,Kammeyer J K,Rush AM,et al. Stimuli-Responsive Nanomaterials for Biomedical Applications[J]. J Am Chem Soc,2015,137:2140-2154.
[27] Wei T,Yu Q,Zhan W,et al. A Smart Antibacterial Surface for the On-demand Killing and Releasing of Bacteria[J]. Adv Healthcare Mater,2016,5(4):449-456.
[28] Albright V,Zhuk I,Wang Y,et al. Self-defensive Antibiotic-Loaded Layer-by-layer Coatings:Imaging of Localized Bacterial Acidification and pH-Triggering of Antibiotic Release[J]. Acta Biomater,2017,61:66-74.
[29] Traba C,Liang J F. Bacteria Responsive Antibacterial Surfaces for Indwelling Device Infections[J]. J Control Release,2015,198:18-25.
[30] Pavlukhina S,Lu Y,Patimetha A,et al. Polymer Multilayers with pH-Triggered Release of Antibacterial Agents[J]. Biomacromolecules,2010,11(12):3448-3456.
[31] Hu Y,Gong X,Zhang J,et al. Activated Charge-Reversal Polymeric Nano-system:The Promising Strategy in Drug Delivery for Cancer Therapy[J]. Polymers,2016,8:99.
[32] Zhang J,Zhu W,Xin B,et al. Development of an Antibacterial Surface with Self-defensive and pH-Responsive Function[J]. Biomater Sci,2019,7:3795-3800.
[33] Zhang, Y,Zhang L,Li B,et al. Enhancement in Sustained Release of Antimicrobial Peptide from Dual-Diameter-Structured TiO₂ Nanotubes for Long-Lasting Antibacterial Activity and Cytocompatibility[J]. ACS Appl Mater Interfaces,2017,9(11):9449-9461.
[34] Chen J,Shi X,Zhu Y,et al. On-Demand Storage and Release of Antimicrobial Peptides Using Pandora's Box-Like Nanotubes Gated with a Bacterial Infection-Responsive Polymer[J]. Theranostics,2020,10(1):109-122.
[35] WANG Yingjun,HUANG Xuelian,CHEN Junjian,et al. Bacterial Infection-Microenvironment Responsive Polymeric Materials for the Treatment of Bacterial Infectious Aiseases:A Review[J]. Mater Rep,2019,33(1):5-15(in Chinese).
王迎军,黄雪连,陈军建,等. 细菌感染微环境响应性高分子材料用于细菌感染性疾病的治疗[J]. 材料导报,2019,33(1):5-15.
[36] Cado G,Aslam R,Séon L,et al. Self-defensive Biomaterial Coating Against Bacteria and Yeasts: Polysaccharide Multilayer Film with Embedded Antimicrobial Peptide[J]. Adv Funct Mater,2013,23(38):4801-4809.
[37] Li X,Wu B,Chen H,et al. Recent Developments in Smart Antibacterial Surfaces to Inhibit Biofilm Formation and Bacterial Infections[J]. J Mater Chem B,2018,6(26):4274-4292.
[38] Rai A,Pinto S,Evangelista M B,et al. High-density Antimicrobial Peptide Coating with Broad Activity and Low Cytotoxicity Against Human Cells[J]. Acta Biomater,2016,33:64-77.
[39] Yu Q,Zhang Y,Wang H,et al. Anti-fouling Bioactive Surfaces[J]. Acta Biomater,2011,7(4):1550-1557.
[40] Wach J Y,Bonazzi S,Gademann K. Antimicrobial Surfaces Through Natural Product Hybrids[J]. Angew Chem Int Ed,2008,47(37):7123-7126.
[41] Yu Q,Wu Z,Chen H. Dual-function Antibacterial Surfaces for Biomedical Applications[J]. Acta Biomater,2015,16:1-13.
[42] Gao G,Lange D,Hilpert K,et al. The Biocompatibility and Biofilm Resistance of Implant Coatings Based on Hydrophilic Polymer Brushes Conjugated with Antimicrobial Peptides[J]. Biomaterials,2011,32(16):3899-3909.
[43] Yu K,Lo J C,Yan M,et al. Anti-adhesive Antimicrobial Peptide Coating Prevents Catheter Associated Infection in a Mouse Urinary Infection Model[J]. Biomaterials,2017,116:69-81.
[44] Gao G,Yu K,Kindrachuk J,et al. Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity[J]. Biomacromolecules,2011,12(10):3715-3727.
[45] Cleophas R T,Sjollema J,Busscher H J,et al. Characterization and Activity of an Immobilized Antimicrobial Peptide Containing Bactericidal PEG-Hydrogel[J]. Biomacromolecules,2014,15(9):3390-3395.
[46] Liu H,Liu X,Meng J,et al. Hydrophobic Interaction-Mediated Capture and Release of Cancer Cells on Thermoresponsive Nanostructured Surfaces[J]. Adv Mater,2013,25(6):922-927.
[47] Yamato M,Akiyama Y,Kobayashi J,et al. Temperature-Responsive Cell Culture Surfaces for Regenerative Medicine with Cell Sheet Engineering[J]. Prog Polym Sci,2007,32(8/9):1123-1133.
[48] Dworak A,Utrata-Wesolek A,Szweda D,et al. Poly[tri(ethylene glycol) Ethyl Ether Methacrylate]-Coated Surfaces for Controlled Fibroblasts Culturing[J]. ACS Appl Mater Interfaces,2013,5(6):2197-2207.
[49] Moroni L,Klein G M,Benetti E M. Polymer Brush Coatings Regulating Cell Behavior: Passive Interfaces Turn into Active[J]. Acta Biomater,2014,10(6):2367-2378.
[50] Lutz J F. Thermo-switchable Materials Prepared Using the OEGMA-Platform[J]. Adv Mater,2011,23(19):2237-2243.
[51] Yu Q,Ista L K,Lopez G P. Nanopatterned Antimicrobial Enzymatic Surfaces Combining Biocidal and Fouling Release Properties[J]. Nanoscale,2014,6(9):4750-4757.
[52] Wang X,Yan S,Song L,et al. Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency[J]. ACS Appl Mater Interfaces,2017,9:40930-40939.
[53] Laloyaux X,Fautre E,Blin T,et al. Temperature-Responsive Polymer Brushes Switching from Bactericidal to Cell-Repellent[J]. Adv Mater,2010,22(44):5024-5028.
[54] Zhan J,Wang L,Zhu Y,et al. Temperature-Controlled Reversible Exposure and Hiding of Antimicrobial Peptides on an Implant for Killing Bacteria at Room Temperature and Improving Biocompatibility in Vivo[J]. ACS Appl Mater Interfaces,2018,10(42):35830-35837.
[55] Yan S,Shi H,Song L,et al. Nonleaching Bacteria-Responsive Antibacterial Surface Based on a Unique Hierarchical Architecture[J]. ACS Appl Mater Interfaces,2016,8(37):24471-24481.
[56] Zhang J,Zhou R,Wang H,et al. Bacterial Activation of Surface-Tethered Antimicrobial Peptides for the Facile Construction of a Surface with Self-defense[J]. Appl Surf Sci,2019,497:143480.
[57] QIAN Yuxin,ZHANG Danfeng,WU Yueming,et al. The Design, Synthesis and Biological Activity Atudy of Nylon-3 Polymers as Mimics of Host Defense Peptides[J]. Acta Polym Sin,2016,10:1300-1311(in Chinese).
钱宇芯,张丹丰,武月铭,等. 模拟宿主防御肽的尼龙3抗菌聚合物结构设计、合成及活性研究[J]. 高分子学报,2016,10:1300-1311.
[58] PAN Shuai,TANG Jianbin. Polymeric Antimicrobial Agents Mimicking the Natural Antimicrobial Peptides[J]. Polym Bull,2011,12:43-49(in Chinese).
潘帅,唐建斌. 模拟天然抗菌多肽高分子抗菌药物的研究进展[J]. 高分子通报,2011,12:43-49.

Recent Progress in the Development of Smart Coatings Based on Antimicrobial Peptides

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