A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine

doi:10.11944/j.issn.1000-0518.2019.12.190099

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (12): 1456-1461.DOI: 10.11944/j.issn.1000-0518.2019.12.190099

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A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine

LIU Xuewen^a^b^*(),TANG Yucai^a^b

^aCollege of Chemistry and Material Engineering,Hunan University of Arts and Science,Changde,Hunan 415000,China
^bState Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China

Received:2019-04-11 Accepted:2019-07-11 Published:2019-12-01 Online:2019-12-10
Contact: LIU Xuewen
Supported by:
Supported by the Research Foundation of Education Bureau of Hunan Province(No.16A145), and the State Key Laboratory of Coordination Chemistry(No.SKLCC1920)

Abstract

Abstract:

A new turn-on type of luminescence probe based on ruthenium(Ⅱ) complex, [Ru(5-CHO-phen)₃]²⁺(5-CHO-phen=1,10-phenanthroline-5-carbaldehyde), has been designed and synthesized. The probe displayed good sensitivity and selectivity toward cysteine (Cys) and homocysteine (Hcy). Enhanced luminescence intensity of this probe displays a good linear relationship in the concentration range of 5 to 35 μmol/L for Cys and Hcy. The detection limit is 0.60 μmol/L and 0.78 μmol/L for Cys and Hcy, respectively. The proposed approach provides a useful method by using luminescence probe based on ruthenoium(Ⅱ) complex for the quantitative detection of various biological molecules.

Key words: cysteine, homocysteine, ruthenium(Ⅱ) complex;, luminescent probe

LIU Xuewen, TANG Yucai. A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine[J]. Chinese Journal of Applied Chemistry, 2019, 36(12): 1456-1461.

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A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine

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