Synthesis and 1,1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments

doi:10.11944/j.issn.1000-0518.2019.05.180296

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (5): 524-531.DOI: 10.11944/j.issn.1000-0518.2019.05.180296

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Synthesis and 1,1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments

SUN Fengmei(),HAN Qiong,ZHAO Panxiang,WANG Jia,RUI Jiayi,XU Jiming

School of Chemistry and Chemical Engineering,Huaiyin Normal University,Huai'an,Jiangsu 223300,China

Received:2018-09-07 Accepted:2018-12-17 Published:2019-05-01 Online:2019-05-06
Contact: SUN Fengmei
Supported by:
Supported by the Jiangsu Province College Students' Practice and Innovation Training Program(No.201810323007Z)

Abstract

Abstract:

Fourteen kinds of salicylaldehyde Schiff bases containing morpholinyl fragments are synthesized by the condensation reaction of 3-fluoro-4-morpholiniline and substituted salicylate and confirmed by nuclear magnetic resonance spectroscopy(NMR), Fourier transform infrared spectrometer(FTIR), liquid chromatography-mass spectrometer(LC-MS) and element analysis. The 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical quenching activities of these Schiff bases are also studied. The results show that all compounds show certain quenching activity of DPPH radicals at concentrations of 0.02 to 0.10 g/L. Among them, the compounds Ⅰd and Ⅰf show excellent properties. The activity of compound Ⅰd is between 30% and 55%, and the activity of compound Ⅰf is more than 50%. With the increase of the concentration of compounds Ⅰd, Ⅰh, Ⅰj and Ⅰn, the DPPH radical quenching activities increase.

Key words: 3-fluoro-4-morpholinine, Schiff base, 1,1-diphenyl-2-picrylhydrazyl radical

SUN Fengmei,HAN Qiong,ZHAO Panxiang,WANG Jia,RUI Jiayi,XU Jiming. Synthesis and 1,1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments[J]. Chinese Journal of Applied Chemistry, 2019, 36(5): 524-531.

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Synthesis and 1,1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments

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