Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (10): 1184-1189.DOI: 10.11944/j.issn.1000-0518.2018.10.170406

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Preparation of 3-Arylthio-4-hydroxycoumarin and Its Analogs

WANG Hongyan(),WEI Xuning   

  1. School of Chemical Engineering and Environment,He'nan University of Technology,Zhengzhou 450001,China
  • Received:2017-11-14 Accepted:2018-03-06 Published:2018-10-01 Online:2018-10-09
  • Contact: WANG Hongyan

Abstract:

4-Hydroxylcoumarin and its analogs are one of the most active classes of heterocyclic compounds. Many of these compounds have been proved to have a wide range of biological and pharmacological activities, such as antibacterial, anti-tumor, anti-HIV. Herein, 3-arylthio-4-hydroxycoumarin and its analogs were synthesized from stable non-toxic 4-hydroxycoumarins, iodobenzenes and sulfur in a cheap and environmentally friendly fashion.

Key words: arylthio-hydroxycoumarin, arylthio-hydroxyquinolinone, aryl-thiolation