Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione

doi:10.11944/j.issn.1000-0518.2016.06.150316

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (6): 677-684.DOI: 10.11944/j.issn.1000-0518.2016.06.150316

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Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione

LI Jie^a,LIU Yilin^b^*(),DENG Youlin^a,WANG Wenxin^a,WANG Shuowen^a,LI Zengzeng^a,TANG Shi^a^*()

^a College of Chemistry and Chemical Engineering,Jishou University,Jishou,Hu'nan 427000,China
^b Huaihua Key Laboratory of Functional Inorganic & Polymeric Materials,Huaihua University,Huaihua,Hu'nan 418008,China

Received:2015-08-31 Accepted:2016-01-11 Published:2016-06-01 Online:2016-06-01
Contact: LIU Yilin,TANG Shi
Supported by:
Supported by the National Natural Science Foundation of China(No.21462017)

Abstract

Abstract:

A visible-light-induced cyclization reaction of activated alkenes leading to difluoroacetating isoquinolinedione was developed. By visible-light photoredox catalysis, various N-alkyl-N-methacryloyl benzamides underwent radical cascade cyclization smoothly and afforded a series of difluoroacetating isoquinolinediones in 66%~75% yields, providing a highly efficient, mild means to fluorinated isoquinolinediones with potential bioactivity.

Key words: visible-light-induced, difluoroacetating, Ir photocatalyst, isoquinolinedione

LI Jie, LIU Yilin, DENG Youlin, WANG Wenxin, WANG Shuowen, LI Zengzeng, TANG Shi. Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione[J]. Chinese Journal of Applied Chemistry, 2016, 33(6): 677-684.

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Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione

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