Factors on Products of 9-Hydroxymethylation Reaction of Fluorene

doi:10.3724/SP.J.1095.2014.30347

Chinese Journal of Applied Chemistry

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Factors on Products of 9-Hydroxymethylation Reaction of Fluorene

YAN Xi, LI Xiaojun^*

(School of Chemical Engineering,Hebei University of Technology,Tianjin 300130,China)

Received:2013-07-15 Revised:2013-09-22 Published:2014-05-10 Online:2014-05-10
Contact: Xiao-jun Li
About author:LI Xiaojun Professor, Tel:022-60202469; Fax:022-26564733; Email:lixiaojun@hebut.edu.cn; Research interest:synthesis of pharmaceutical and fine chemical intermediates

Abstract

Abstract: Given acidic protons on the 9 position, flourene undergoes hydroxymethylation reaction with paraformaldehyde in the presence of base. The effects of bases, reaction temperature and reaction time on the distribution of products were studied. The results indicate that the stronger the base, the more 9,9-bishydroxymethylflourene is produced. In the meanwhile, elevated reaction temperature and prolonged the reaction time result in more 9,9′-methylene diflourene. By controlling the reaction conditions intentionally it is possible to produce 9-fluorenyl methanol or 9,9-bishydroxymethylflourene selectively or both in one pot.

Key words: fluorene, hydroxymethylation reaction, fluorenyl methanol, bishydroxymethylfluorene

CLC Number:

O625.3

YAN Xi, LI Xiaojun*. Factors on Products of 9-Hydroxymethylation Reaction of Fluorene[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30347.

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Factors on Products of 9-Hydroxymethylation Reaction of Fluorene

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