Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent

doi:10.3724/SP.J.1095.2013.30156

Chinese Journal of Applied Chemistry

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Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent

ZHAO Guiyan^1,2, XU Jingwei^1*, YANG Wei^1*

(1.The State Key Laboratory of Electroanalytical-Chemistry,Changchun Institute of
Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
2.University of the Chinese Academy of Sciences,Beijing 100049,China)

Received:2013-04-01 Revised:2013-04-22 Published:2014-02-10 Online:2014-02-10
Contact: wei Yang

Abstract

Abstract: A binuclear gadolinium(Ⅲ) complex, [Gd2(TP(DTTA)2)(H2O)4]2-, containing two DTTA-Gd paramagnetic units(DTTA=diethylenetriamine-N,N,N″,N″-tetraacetate) bridged by a terephthaloyl(TP) core has been synthesized and evaluated as a potential magnetic resonance imaging(MRI) contrast agent. The relaxation measurements indicate that the dinuclear gadolinium(Ⅲ) complex has a much higher relaxivity than that of the previously reported dinuclear DTTA-based agent(21.7 L/(mmol·s) per Gd3+ vs 12.8 L/(mmol·s) at 20 MHz, 37 ℃ and pH=7). Moreover, the luminescence lifetime measurements on the analogue terbium Tb2(TP(DTTA)2) give the inner-sphere hydration number of q=1.4. The results show that a more rigid linker in dinuclear MRI contrast agents is helpful for relaxivity improvement.

Key words: magnetic resonance imaging, multinuclear contrast agents, high relaxivity}rigid linker, Gd-DTTA

CLC Number:

O482.5

ZHAO Guiyan1,2, XU Jingwei1*, YANG Wei1*. Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.30156.

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Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent

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