Abstract: Some vanadium-substituted hetropolytungstates were synthesized.Their toxicityto the cells of RK and activity to antipseudorabies virus at nontoxic concentrations were tested by cell-culture methods.The results showed that some of the compounds had high antiPRV activity at nontoxic concentration.Among them three had high antivirus and selectiveactivity with median effective concentration 3.2～5.0 mg/L and cell median toxicity concentration 400～420 mg/L.At concentration of the compounds 12.5 mg/L the inhibition toPRV was more than 70%～80%, while virus TCID50 values descended four log.The relationbetween the structure and activity has been discussed briefly.

Key words: vanadium-substituted heteropolytungstate, antivirus activity, pseudorabies virus