Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (05): 521-525.DOI: 10.3724/SP.J.1095.2011.00402
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DONG Yan, LIU Zuliang*, YUAN Chengliang
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Abstract:
A new synthetic route to 5-amino-6-nitro-[1,2,5] oxadiazolo[3,4-b]pyridine-1-oxide was developed using 2,6-dichloropyridine as starting materials via four steps, including hydrazinolysis, reduction, nitration and Nietzki-Dietschy cyclization. The effects of these reactions were investigated based on their reaction mechanisms. On the basis of these results, the reaction was optimized and the overall yield of target product was up to 59.2%. The product was characterized by 1HNMR, MS and IR.
Key words: amino-nitro-[1,2,5] oxadiazolo[3,4-b]pyridineoxide, dichloropyridine, Cure reactive mechanism, overall yield
CLC Number:
O626.3
DONG Yan, LIU Zuliang*, YUAN Chengliang. A New Synthetic Route of 5-Amino-6-nitro-[1,2,5] oxadiazolo[3,4-b]pyridine-1-oxide[J]. Chinese Journal of Applied Chemistry, 2011, 28(05): 521-525.
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URL: http://yyhx.ciac.jl.cn/EN/10.3724/SP.J.1095.2011.00402
http://yyhx.ciac.jl.cn/EN/Y2011/V28/I05/521