Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (05): 521-525.DOI: 10.3724/SP.J.1095.2011.00402

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A New Synthetic Route of 5-Amino-6-nitro-[1,2,5] oxadiazolo[3,4-b]pyridine-1-oxide

DONG Yan, LIU Zuliang*, YUAN Chengliang   

  1. (Chemical Engineering School,Nanjing University of Science & Technology,Nanjing 210094)
  • Received:2010-07-09 Revised:2010-10-04 Published:2011-05-10 Online:2011-05-10

Abstract:

A new synthetic route to 5-amino-6-nitro-[1,2,5] oxadiazolo[3,4-b]pyridine-1-oxide was developed using 2,6-dichloropyridine as starting materials via four steps, including hydrazinolysis, reduction, nitration and Nietzki-Dietschy cyclization. The effects of these reactions were investigated based on their reaction mechanisms. On the basis of these results, the reaction was optimized and the overall yield of target product was up to 59.2%. The product was characterized by 1HNMR, MS and IR.

Key words: amino-nitro-[1,2,5] oxadiazolo[3,4-b]pyridineoxide, dichloropyridine, Cure reactive mechanism, overall yield

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