Abstract:

The enthalpies of dissolution of paclitaxel in dimethylsulfoxide(DMSO) was reported. The differential enthalpy(Δ_difH_m) and the molar enthalpy(Δ_solH_m) were determined, and the relationship between the amount of heat released and the amount of solute was also established. The corresponding kinetic equation that describes the dissolution process is da/dt=2.92×10^-4×(1-a)^1.00, and the kinetic parameters are obtained as follows:t_1/2=50.43 min， Δ_solH_m=32.67 kJ/mol, and Δ_solS_m=-204.93 J/(mol·K). The result not only provides a simple method for the determination of the half-life for drugs, but it can also offer a theoretical reference for the clinical application of paclitaxel using microcalorimeter.

Key words: thermodynamics, kinetics, dissolution heat, paclitaxel, dimethylsulfoxide