缓释型壳聚糖/醋酸氯己定复合微球的制备与性能

doi:10.19894/j.issn.1000-0518.210014

摘要/Abstract

摘要： 医院获得性感染(HAIs)是现代临床医学中的巨大挑战,开发长效的抗菌材料对于改善医疗和人民健康具有重要意义。本文采用乳化法制备壳聚糖/醋酸氯己定(CS/CHXA)复合微球,通过调控制备参数控制复合微球的大小和交联度,进而改变CS与CHXA的复合比例、交联剂用量与时间等条件,控制CHXA的载药量和缓释性能。通过将CS/CHXA复合微球添加至醋酸乙烯-乙烯共聚乳液(VAE)中,制备均匀分散的乳液并涂覆于橡胶管表面,实现了CHXA的长时间释放,涂覆在橡胶管表面的涂层具有长效抗菌性,最终有望实现橡胶管的长效抗菌。

关键词: 壳聚糖复合微球, 醋酸氯己定, 缓释, 抗菌性能

Abstract: Hospital acquired infections (HAIs) is a great challenge in modern clinical medicine. It is of great significance to develop effective antibacterial materials for improving medical treatment and people′s health. In this research, chitosan/chlorhexidine acetate composite microspheres (CS/CHXA) are prepared by an emulsifying method. The size and crosslinking degree of the composite microspheres are controlled by regulating the preparation methods and parameters, the loading efficiency and slow release property of chlorhexidine acetate are controlled by changing the compound ratio of chitosan and chlorhexidine acetate, the dosage and time of crosslinking agent. Furthermore, the composite microspheres are added to vinyl acetate-ethylene copolymer emulsion (VAE) to prepare well dispersed emulsion and subsequently coated on the surface of rubber hose, which is expected to achieve long-term antibacterial effect of rubber hose. The prepared VAE/CS/CHXA shows long-term antibacterial properties of rubber hose.

Key words: Chitosan composite microspheres, Chlorhexidine acetate, Sustained release, Antibacterial property

中图分类号:

O636

林秋棚, 章朱迎, 施冬健, 裴泽军, 陈明清, 倪忠斌. 缓释型壳聚糖/醋酸氯己定复合微球的制备与性能[J]. 应用化学, 2021, 38(12): 1599-1611.

LIN Qiu-Peng, ZHANG Zhu-Ying, SHI Dong-Jian, PEI Ze-Jun, CHEN Ming-Qing, NI Zhong-Bin. Preparation and Properties of Sustained Release Chitosan/Chlorhexidine Acetate Composite Microspheres[J]. Chinese Journal of Applied Chemistry, 2021, 38(12): 1599-1611.

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