活性炭负载硫酸催化合成环戊并[d]嘧啶酮和六氢喹唑啉酮

doi:10.19894/j.issn.1000-0518.190334

摘要/Abstract

摘要： 制备了一种活性炭负载硫酸催化剂(H₂SO₄/AC),利用傅里叶变换红外光谱仪(FT-IR)和X射线衍射仪(XRD)表征了其形貌。在该催化剂作用下,以芳醛、尿素、环戊酮(环己酮)为原料,在无溶剂条件下经三组分一锅法反应合成了系列环戊并[d]嘧啶酮(六氢喹唑啉酮)。该方法用于合成此两类化合物操作简单,对环境友好,具有良好的应用前景。催化剂易于回收和循环使用,可重复使用3次,仍保持较高活性。

关键词: 活性炭负载硫酸, 环戊并[d]嘧啶酮, 六氢喹唑啉酮, 多组分反应

Abstract: An activated carbon supported sulfuric acid catalyst (H₂SO₄/AC) was prepared and characterized by Fourier transform infrared (FT-IR) spectrometry and X-ray diffraction (XRD). Various cyclopenta[d]pyrimidinones and hexahydroquinazolinones were synthesized by the reaction of aromatic aldehyde with urea and cyclopentone(cyclohexanone) catalyzed by H₂SO₄/AC in the absence of solvent. This method is simple and environmentally benign. The catalyst can be easily recovered and its activity maintains after being reused for 3 times.

Key words: Activated carbon supported sulfuric acid, Cyclopenta[d]pyrimidinones, Hexahydroquinazolinones, Multicomponent reactions

中图分类号:

O621.3

任丽磊, 肖立伟, 刘光仙, 徐明明. 活性炭负载硫酸催化合成环戊并[d]嘧啶酮和六氢喹唑啉酮[J]. 应用化学, 2021, 38(1): 44-50.

REN Li-Lei, XIAO Li-Wei, LIU Guang-Xian, XU Ming-Ming. Synthesis of Cyclopenta[d]pyrimidinones and Hexahydroquinazolinones Catalyzed by Activated Carbon Supported Sulfuric Acid[J]. Chinese Journal of Applied Chemistry, 2021, 38(1): 44-50.

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