基于大环分子的主客体超分子荧光探针

doi:10.11944/j.issn.1000-0518.2017.12.170301

摘要/Abstract

摘要：

针对环境污染源的早期检测和疾病的预防与治疗已经研究开发出许多检测技术手段,其中,荧光探针作为一种方便、灵敏、可视化的检测技术得到了广泛关注与认可。大环分子荧光探针作为一类重要的荧光探针逐渐引起了研究者的关注。大环分子具有特定尺寸、可特异性配合某些基团的空腔。因此,在设计这类荧光探针时可以充分利用大环分子的空腔优势。此外,大环分子容易通过化学修饰制备多种功能化衍生物,这也为设计大环荧光探针提供了更多选择。本文回顾了大环分子荧光探针的设计策略,主要从探针的化学组成以及相互作用机理来阐述,为大环分子荧光探针的设计提供了系统的理论指导。

关键词: 荧光分子探针, 大环分子, 荧光发色团, 超分子设计策略, 可视化检测

Abstract:

A number of detection techniques have been developed for the early detection of environmental pollutants and health hazard substances, the prevention and treatment of diseases. Among them, fluorescent probe technique as a convenient, sensitive and visual method has been widely applied. Macrocyclic supramolecular fluorescent probes have gradually attracted the attention of the scientific community. Macrocyclic molecules possess cavities with certain size, which could complex with specific groups to form supramolecules. Therefore, in the design of supramolecular fluorescent probes, the cavity advantage of macrocyclic molecules can be taken into consideration and utilized. In addition, due to easy functionalization, a variety of functional macrocyclic molecules have been synthesized, providing more choices for the design of macrocyclic supramolecular fluorescent probes. This paper reviews the design strategies of macrocyclic supramolecular fluorescent probes with focuses on the chemical composition and detection mechanisms of the probe, which might provide a systematic theoretical guidance for the design of supramolecular fluorescent probes.

Key words: macrocyclic molecule, fluorophore, supramolecular fluorescent probes, design strategies

姚倩芳,程文玉,尹梅贞. 基于大环分子的主客体超分子荧光探针[J]. 应用化学, 2017, 34(12): 1344-1354.

YAO Qianfang,CHENG Wenyu,YIN Meizhen. Host-Guest Supramolecular Fluorescent Probes Based on Macrocyclic Molecules[J]. Chinese Journal of Applied Chemistry, 2017, 34(12): 1344-1354.

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