N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用

doi:10.11944/j.issn.1000-0518.2017.05.160286

摘要/Abstract

摘要：

以苯乙酮衍生物为原料,N-甲基吡咯烷酮替代甲醛类似物,考察了其作为一碳合成子在曼尼希反应中的应用。在最优条件下,以46%~93%的收率成功合成了系列曼尼希碱衍生物。该反应底物范围宽泛,官能团兼容性好,并且初步研究了该反应的机理。

关键词: 曼尼希碱, N-甲基吡咯烷酮, 一碳合成子, C—C键形成, C—N键形成

Abstract:

With acetophenone derivatives as raw materials, we reported the application of N-methyl-2-pyrrolidone as one carbon synthon to replace formaldehyde analogues in the Mannich reaction. Under optimal reaction conditions, a series of mannich base derivatives were obtained with 46%~93% yield. This reaction shows a broad substrate scope and good functional groups compatibility. The preliminary mechanism of the reaction was also studied.

Key words: Mannich base, N-methyl-pyrrolidinone, one carbon synthon, C—C bond formation, C—N bond formation

王薪,孙凯. N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用[J]. 应用化学, 2017, 34(5): 534-540.

WANG Xin,SUN Kai. Application of N-Methyl-2-pyrrolidinone as One Carbon Synthon in Mannich Reactions[J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 534-540.

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