可见光诱导烯烃环化合成二氟烷基化异喹啉二酮

doi:10.11944/j.issn.1000-0518.2016.06.150316

摘要/Abstract

摘要：

发展了一种可见光诱导的活泼烯烃串联自由基环化合成含氟异喹啉二酮的反应。在可见光诱导下,多种N-烷基-N-甲基丙烯酰基苯甲酰胺与二氟溴乙酸乙酯发生自由基串联环化反应,以66%~75%的产率合成了一系列具有潜在生理活性的二氟烷基化异喹啉二酮。此研究为合成具有潜在药用价值的氟取代异喹啉二酮提供了一条高效、条件温和的途径。

关键词: 可见光诱导, 二氟烷基化, 铱光催化剂, 异喹啉二酮

Abstract:

A visible-light-induced cyclization reaction of activated alkenes leading to difluoroacetating isoquinolinedione was developed. By visible-light photoredox catalysis, various N-alkyl-N-methacryloyl benzamides underwent radical cascade cyclization smoothly and afforded a series of difluoroacetating isoquinolinediones in 66%~75% yields, providing a highly efficient, mild means to fluorinated isoquinolinediones with potential bioactivity.

Key words: visible-light-induced, difluoroacetating, Ir photocatalyst, isoquinolinedione

李捷, 刘益林, 邓佑林, 王文新, 王硕文, 李增增, 唐石. 可见光诱导烯烃环化合成二氟烷基化异喹啉二酮[J]. 应用化学, 2016, 33(6): 677-684.

LI Jie, LIU Yilin, DENG Youlin, WANG Wenxin, WANG Shuowen, LI Zengzeng, TANG Shi. Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione[J]. Chinese Journal of Applied Chemistry, 2016, 33(6): 677-684.

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