应用化学 ›› 2016, Vol. 33 ›› Issue (4): 406-411.DOI: 10.11944/j.issn.1000-0518.2016.04.150312

• 研究论文 • 上一篇    下一篇

粒径和孔径可控的多孔交联聚苯乙烯微球的制备

黄广诚ab,邱比特a,刘亚栋a,赵辉c,季生象a*()   

  1. a中国科学院长春应用化学研究所 长春 130022
    b中国科学院大学 北京 100049
    c山西科瑞迪生物科技有限公司 太原 030032
  • 收稿日期:2015-08-28 接受日期:2015-12-09 出版日期:2016-04-01 发布日期:2016-04-01
  • 通讯作者: 季生象
  • 基金资助:
    国家国际科技合作专项基金项目(2012DFA50740)国家自然科学基金项目(51173181,51373166)

Synthesis and Characterization of Crosslinked Porous Poly(styrene-co-divinylbenzene) Microspheres with Tunable Particle and Pore Diameters

HUANG Guangchengab,QIU Bitea,LIU Yadonga,ZHAO Huic,JI Shengxianga*()   

  1. a Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    bUniversity of Chinese Academy of Sciences,Beijing 100049,China
    cShanxi Keruidi Biotechonology Co. Ltd.,Taiyuan 030032,China
  • Received:2015-08-28 Accepted:2015-12-09 Online:2016-04-01 Published:2016-04-01
  • Contact: JI Shengxiang
  • Supported by:
    Supported by the Special Foundation of Ministry of Science and Technology International S&T Cooperation(No.2012DFA50740), the National Natural Science Foundation of China(No.51173181, No.51373166), Chinese Academy of Sciences “

摘要:

采用悬浮聚合方法合成了多孔交联聚苯乙烯微球,研究发现微球的粒径与分散剂含量、水油比、搅拌速度和成孔剂有关,而微球的孔径与成孔剂的种类和含量有关。 增加分散剂的用量,提高水油比和加快搅拌速度都能导致微球的粒径减小。 微球的孔径和粒径均随着成孔剂与聚合物溶度参数差值变大而增加。通过改变以上条件得到粒径为100~300 μm和孔径为8~36 nm的交联度为27%的多孔交联聚苯乙烯微球,并利用光学显微镜、场发射扫描电子显微镜(SEM)和氮气吸附解吸法对微球进行了相应的表征。 得到的微球在固相合成载体中有一定的应用前景。

关键词: 悬浮聚合, 多孔微球, 交联微球

Abstract:

Crosslinked porous poly(styrene-co-divinylbenzene) microspheres with tunable particle and pore diameters were synthesized by suspension polymerization and characterized by optical microscopy, SEM and N2 adsorption-desorption isotherm. The particle diameters can be controlled by tuning the content of poly(vinyl alcohol), the water-oil ratio, the stirring rate and the amount of porogen. At the same time, the pore diameters can be tuned by adjusting the type and amount of porogens and the ratio of mixed porogens. The particle diameters decrease with the increase of the amount of PVA, the water-oil ratio and the stirring rate. Both the particle and pore diameters increase with the increase of the amount of porogen and the difference in solubility parameters between the polymer and the porogen. The particle and pore diameters of crosslinked microspheres with 27% crosslinking density are controlled in the range of 100~300 μm and 8~36 nm, respectively. These porous poly(styrene-co-divinylbenzene) microspheres are suitable supports for solid phase synthesis.

Key words: suspension polymerization, porous sphere, crosslinked particle