醋酸酮催化二硫醚与四氢呋喃的氧化偶联反应

doi:10.11944/j.issn.1000-0518.2015.11.150124

摘要/Abstract

摘要：

研究了醋酸酮催化二硫醚与四氢呋喃以氧化偶联反应构建C—S键。结果表明,在醋酸酮(10%摩尔分数)、二硫醚(0.5 mmol)、四氢呋喃(2 mL)和双氧水(35%,2倍化学计量),反应温度120 ℃条件下,二硫醚与四氢呋喃能够顺利地发生氧化偶联反应,生成相应的C—S键化合物,合成硫醚类化合物产率中等到良好。该反应以双氧水为氧化剂,具有环境友好等特性。

关键词: 醋酸酮, 二硫醚, 四氢呋喃, 氧化偶联反应, 双氧水

Abstract:

A new Cu(OAc)₂-catalyzed oxidative coupling of disulfides with tetrahydrofuran for the synthesis of etherified sulfides has been developed. In the presence of Cu(OAc)₂(10% molar fraction) and H₂O₂(35%, 2 equiv), a variety of disulfides(0.5 mmol) were treated with tetrahydrofuran(2 mL) at 120 ℃ to afford the corresponding etherified sulfides in moderate to high yields. This method employs 35% aqueous H₂O₂ as the green oxidant, and provides an efficient way for the formation of the C—S bonds.

Key words: copper acetate, disulfides, tetrahydrofuran, oxidative coupling reaction, H2O2

周芸,刘卉,何艳,李爱桃,陶李明. 醋酸酮催化二硫醚与四氢呋喃的氧化偶联反应[J]. 应用化学, 2015, 32(11): 1253-1258.

ZHOU Yun,LIU Hui,HE Yan,LI Aitao,TAO Liming. Copper Acetate Catalyzed Oxidative Coupling of Disulfides with Tetrahydrofuran[J]. Chinese Journal of Applied Chemistry, 2015, 32(11): 1253-1258.

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