应用化学 ›› 2015, Vol. 32 ›› Issue (2): 123-133.DOI: 10.11944/j.issn.1000-0518.2015.02.140187

• 综合评述 • 上一篇    下一篇

氨基二硫代甲酸酯类化合物生物活性研究进展

王晓娟*, 李高伟, 孟团结, 刘澜涛, 赵文献*   

  1. 商丘师范学院化学化工学院 河南 商丘 476000
  • 收稿日期:2014-05-23 修回日期:2014-08-11 出版日期:2015-02-10 发布日期:2015-02-10
  • 通讯作者: 赵文献,教授; Tel/Fax:0370-2595126; E-mail:zhwx5126@gmail.com; 研究方向:有机合成方法学和药物化学
  • 基金资助:
    国家自然科学基金(21172139,21202095)河南省教育厅科学技术研究重点项目(13A150835,14A150055)资助

Research Progress in the Bioactivities of the Dithiocarbamates

WANG Xiaojuan*, LI Gaowei, MENG Tuanjie, LIU Lantao, ZHAO Wenxian*   

  1. School of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu,He'nan 476000,China
  • Received:2014-05-23 Revised:2014-08-11 Published:2015-02-10 Online:2015-02-10
  • Contact: Corresponding author:ZHAO Wenxian, professor; Tel/Fax:0370-2595126; E-mail:zhwx5126@gmail.com; Research interests:organic methodology and medicinal chemistry
  • Supported by:

    ; Supported by the National Natural Science Foundation of China (Nos.21172139, 21202095) and the Education Department of He'nan Province Science and Technology Research Projects(No.13A150835, No.14A150055)

摘要:

氨基二硫代甲酸酯类化合物由于其独特的分子结构,使其具有明显的抗肿瘤、抗菌、抗氧化以及杀虫等多种生物活性,已经成为近年来药物化学领域研究的重点。 本文评述了近年来文献报道的氨基二硫代甲酸酯类化合物以及它们的主要生物活性,并对其今后的发展方向、应用前景做出展望。

关键词: 氨基二硫代甲酸酯, 生物活性

Abstract:

Dithiocarbamate compounds have become the focus of pharmaceutical chemistry in recent years due to their unique molecular structure with a variety of biological properties, such as anti-tumor, antibacterium, antioxidation and insecticidal activity. This article reviews recent progresses in the biological activities of dithiocarbamate compounds and gives prospects for their development and application.

Key words: dithiocarbamates, bioactivities

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