2-甲基-1,8-萘啶衍生物的甲基溴代反应

doi:10.3724/SP.J.1095.2014.30642

摘要/Abstract

摘要： 报道了2-甲基-1,8-萘啶衍生物的甲基溴化反应，以N-溴代琥珀酰亚胺(NBS)为溴化剂、红外光为引发剂，得到单溴代产物2-溴甲基-1,8-萘啶衍生物及其二溴代副产物2-二溴甲基-1,8-萘啶衍生物，对比了两种不同的反应条件，通过对影响甲基溴化产物产率的反应条件进行优化改进，得到单溴代产物的较优合成条件为：NBS的用量为原料的1.2倍，500 W红外灯为光源，反应时间为2 h。该反应条件下，单溴代产物的产率可达到54.6%。

关键词: 萘啶, N-溴代琥珀酰亚胺, 引发剂

Abstract: This paper reported the bromination of 2-methyl-1,8-naphthyridine derivatives. Monobrominated products, 2-bromomethyl-1,8-naphthyridine derivatives, and dibrominated byproducts were obtained with N-bromosuccimide(NBS) as the bromination agent under infrared light. Two synthetic conditions were evaluated. The yield of monobrominated products is up to 54.6% under the optimized condition of 2-methyl-1,8-naphthyrdine derivatives and NBS in molar ratio of 1∶1.2 under 500 W infrared light.

Key words: naphthyridine, N-bromosuccinimide, initiator

中图分类号:

O626.3

苟高章, 吴娜, 石玲, 徐世娟, 严和平, 刘卫. 2-甲基-1,8-萘啶衍生物的甲基溴代反应[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30642.

GOU Gaozhang1,2, WU Na1,2, SHI Ling1,2, XU Shijuan1,2, YAN Heping1,2, LIU Wei1,2*. Bromination of 2-Methyl-1,8-naphthyridine Derivatives[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30642.

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