应用化学

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微反应器在合成化学中的应用

何伟1,方正1,陈克涛2,万志东1,郭凯3*   

  1. (南京工业大学1.药学院;2.食品与轻工学院;3.生物与制药工程学院 南京 210009)
  • 收稿日期:2012-12-31 修回日期:2013-05-03 出版日期:2013-12-10 发布日期:2013-12-10
  • 通讯作者: 郭凯,教授; Tel:025-58139926; Fax:025-5813997; E-mail:kaiguo@njut.edu.cn; 研究方向:药物合成、微反应器等
  • 基金资助:
    国家重点基础研究发展计划(973计划,2012CB725204, 2012CB721104)

Application of Microreactor Technology in Synthetic Chemistry

HE Wei1, FANG Zheng1, CHEN Ketao2, WANG Zhidong1, GUO Kai3*   

  1. (1.School of Pharmaceutical;2.College of Sciences;3.College of Biotechnology and
    Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China)
  • Received:2012-12-31 Revised:2013-05-03 Published:2013-12-10 Online:2013-12-10

摘要: 微反应器在传质、换热方面具有较明显的优势,可以强化混合和精确控温,还可以大大缩短工艺筛选和工艺放大的周期。 本文着重从液相反应、气相反应和气/液反应3个方面对微反应技术在合成中的应用做了较详细的评述,同时也简略介绍了其在光化学和电化学反应中的应用,并概要介绍了微反应技术现阶段存在的问题。

关键词: 微反应器, 传热, 传质, 液相反应, 气相反应, 气液反应

Abstract: Micro Reactor Technique(MRT), which shows great advantages in heat transfer, mass transfer and mixing, can enhance the mixing process and control the reaction temperature precisely. In addition, it can dramatically shorten the screening period and scale-up process. This review emphasized the application of the microreactor technology in liquid phase reaction, gas phase reaction and gas-liquid phase reaction in detail. Meanwhile, photochemistry and electrochemistry were introduced briefly. We also presented the existing problems in such technique.

Key words: microreactor, heat transfer, mass transfer, liquid phase microreaction, gas phase microreaction, gas-liquid phase microreaction

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