中华医学超声杂志

应用化学

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邻氯苯甲腈的新合成法

朱益忠1*,张喜全1,刘飞1,顾红梅1,朱海亮2*   

  1. (1.江苏正大天晴药业股份有限公司 南京 210042；
    2.南京大学生命科学学院医药生物技术国家重点实验室 南京 210093)
  • 收稿日期:2012-11-16 修回日期:2013-01-29 出版日期:2013-08-10 发布日期:2013-08-10
  • 通讯作者: 朱益忠,工程师; Tel:025-68551613; Fax:025-68551609; E-mail:zhuyzhong@yahoo.cn; 研究方向：药物合成
  • 基金资助:
    江苏省博士后基金

A New Synthetic Route Toward o-Chlorobenzonitrile

ZHU Yizhong1*, ZHANG Xiquan1, LIU Fei1, GU Hongmei1, ZHU Hailiang2*   

  1. (1.Jiangsu Chiatai Tianqing Pharmaceutical Co. Ltd.,Nanjing 210042,China;
    2.State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210093,China)
  • Received:2012-11-16 Revised:2013-01-29 Published:2013-08-10 Online:2013-08-10

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摘要： 以邻氯溴苯为起始原料,选用K4[Fe(CN)6]为氰基化试剂，Pd/C催化反应制得邻氯苯甲腈。 考察了温度、碱、催化剂的用量和原料比等对反应的影响，确定了较佳反应条件。 邻氯溴苯转化率达98.5%，产物邻氯苯甲腈得率95.1%。

关键词: 邻氯溴苯, K4[Fe(CN)6], 氰基化反应

Abstract: o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst. The reaction conditions were optimized through investigating the reaction temperature, base, the amount of catalyst, the ratio of reactants. The conversion of the o-chlorobromobenzene to target product could reach 98.5% and the yield of o-chlorobenzonitrile was 95.1%.

Key words: o-chlorobromobenzene, potassium ferrocyanide, cyanization reaction

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