中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (4): 89-91.

• 研究论文 • 上一篇    下一篇

手性2-(2-吡啶基)-4-甲酯基-1,3-噻唑烷的合成及应用

姚金水1, 武玉民1, 李弘2, 何炳林2   

  1. 1. 山东轻工业学院化学工程系 济南 250100;
    2. 吸附与分离功能高分子材料国家重点实验室, 南开大学高分子化学研究所 天津
  • 收稿日期:1997-10-27 修回日期:1998-04-15 出版日期:1998-08-10 发布日期:1998-08-10

Synthesis and Application of Chiral 2-(2-Pyridyl)4-carbomethoxy-1,3-thiazolidine

Yao Jinshui1, Wu Yumin1, Li Hong2, He Binglin2   

  1. 1. Department of Chemical Engineering, Shandong Institute of Light Industry, Ji'nan 250100;
    2. The State Key Laboratory of Functirnial Polymeric Materials for Adsorption and Separation, lnstitute of Polymer Chemistry, Nankai University, Tianjin
  • Received:1997-10-27 Revised:1998-04-15 Published:1998-08-10 Online:1998-08-10

PDF

399

被引次数

1

摘要： 不对称氢化硅烷化可实现由含碳碳或碳杂双键的化合物合成手性醇和手性胺,在石油化工、药物合成、生物碱等生物活性物质的合成等领域具有潜在的应用价值.90年代以来,不断有高活性、高选择性的手性催化剂的开发研究报道[1~4],使不对称硅氢化研究成为催化科学的一个研究方向.我们开展了带有毗啶取代基的噻唑烷类手性络合催化剂的研究工作[5,6].

关键词: 吡啶基-甲酯基噻唑烷, 手性配体, 不对称氢化硅烷化

Abstract: The title ligand(A) was synthesized through condensation of 2-pyridine aldehydeand L-methyl cysteine hydrochloride.The isomers of (A) were separated by column chromatography.The in-situ prepared catalyst from (A) with [Rh(COD)CI]2(COD:cyclooctadiene) has been used to catalyze the asymmetric hydrosilylation of acetophenone.The resultsshowed that only the configuration of C4, but not that of C2 affected the optical yield andconfiguration of the products.

Key words: pyridyl-carbomethoxy-thiazolidine, ligand, asymmetric hydrosilylation

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