中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (5): 67-70.

• 研究论文 • 上一篇    下一篇

中西药结合抗菌性甲壳胺复合膜的制备及其体外释放

方月娥1, 吕小斌1, 王永明1, 周涛1, 冯建平1, 陈柏钧2, 李立生2, 王永杰2, 王少根2   

  1. 1. 中国科学技术大学应用化学系, 结构分析开放实验室, 合肥 230026;
    2. 安徽医科大学第一附属医院, 合肥
  • 收稿日期:1996-12-31 修回日期:1997-07-10 出版日期:1997-10-10 发布日期:1997-10-10
  • 基金资助:
    安徽省自然科学基金

Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs

Fang Yue'e1, L? Xiaobin1, Wang Yongming1, Zhou Tao1, Feng Jianping1, Chen Bojun2, Li Lisheng2, Wang Yongjie2, Wang Shaogen2   

  1. 1. Department of Applied Chemistry, University of Science andTechnology of China, Hefei 230026;
    2. First Affiliated Hospital of Anhui Medical University, Hefei
  • Received:1996-12-31 Revised:1997-07-10 Published:1997-10-10 Online:1997-10-10

PDF

459

被引次数

19 | 3

摘要： 利用甘油作为增塑剂,制备了以甲壳胺/淀粉/聚乙烯醇为基材的含有原儿茶酸(对烧伤、创伤有特效的中药)和环丙沙星(杀菌性能最强的抗菌剂)等的复合型生物敷料,研究了不同条件下制备的敷料膜其抗菌剂在林格试剂中的静态释放情况,并对释放机理进行了探讨。

关键词: 甲壳胺复合膜, 原儿茶酸, 环丙沙星, 药物释放

Abstract: A novel composite membrane based on chitosan/starch/polyvinyl alcohol was prepared by solvent casting technique and its mechanical properties were measured. The drug release and its mechanism in static state from the composite membranes containing ciprofloxacin and protocatechuic acid have been investigated. The release rate was found to be controlled by the starch content in membrane matrices as well as by crosslinking state.

Key words: chitosan composite membrane, protocatechuic acid, ciprofloxacin, drug release

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