中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (4): 25-28.

• 研究论文 • 上一篇    下一篇

氯硝柳胺透皮控释给药的研究

戚国荣1, 杨云松1, 杨士林1, 章国林2, 张庆地2   

  1. 1. 浙江大学高分子科学与工程学系, 杭州 310027;
    2. 浙江医科大学药学系, 杭州
  • 收稿日期:1996-10-20 修回日期:1997-05-26 出版日期:1997-08-10 发布日期:1997-08-10
  • 基金资助:
    国家自然科学基金

Study on the Niclosamide Transdermal Therapeutic System

Qi Guorong1, Yang Yunsong1, Yang Shilin 1, Zhang Guolin2, Zhang Qingdi2   

  1. 1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027;
    2. Department of Pharmacy, Zhejiang Medical University, Hangzhou
  • Received:1996-10-20 Revised:1997-05-26 Published:1997-08-10 Online:1997-08-10

PDF

701

被引次数

25 | 3

摘要： 用Valia-Chien双室扩散池进行了氯硝柳胺体外透皮的研究，发现氯硝柳胺乙醇混悬液有较高的渗透速率且服从零级动力学模型，透皮促进剂油酸比氮酮具有更好的促渗作用，氮酮与丙二醇或油酸合用均有协同作用。研究结果表明，氯硝柳胺能制成长效贴剂，且在23～72h之间缓慢平稳释药。用IR、DSC研究了氮酮和油酸的作用机理。

关键词: 氯硝柳胺, 透皮给药, 氮酮, 油酸

Abstract: The efficiency of penetration enhancers for niclosamide has been studied using double cell skin permeation system. It was found that oleic acid was a good enhancer for niclosamide and was more efficient than azone. Azone showed a synergism with oleic acid or propylene glycol. It was also demonstrated that niclosamide could be used as a long-lasting liniment. The mechanism of the effect of azone and oleic acid has been investigated by IR and DSC techniques.

Key words: niclosamide, transdermal therapeutic system, azone, oleic acid

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