应用化学 ›› 1997, Vol. 0 ›› Issue (1): 71-73.

• 研究论文 • 上一篇    下一篇

对烷氧基苯甲醛合成方法的改进

董恒山, 杨世琰, 殷元骐   

  1. 中国科学院兰州化学物理研究所 兰州 730000
  • 收稿日期:1996-04-18 修回日期:1996-08-09 出版日期:1997-02-10 发布日期:1997-02-10

An Improved Synthetic Method for p-Alkoxybenzaldehydes

Dong Hengshan, Yang Shiyan, Yin Yuanqi   

  1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
  • Received:1996-04-18 Revised:1996-08-09 Published:1997-02-10 Online:1997-02-10

摘要: 对烷氧基苯甲醛是合成液晶材料和有机合成的重要中间体,在许多液晶合成中都有应用[1~3]. 通常用 William son 醚合成法合成,文献上报道的改进方法很多. 对烷氧基上烷基是 正构长链的合成方法主要有: 对羟基苯甲醛在碱性条件下,使用各种卤代烷,以酮或 DMF 为溶剂,烷基化而制得[4~6] ; 卤代烷和 4-羟基苯甲醛在碱性条件下使用相转移催化剂进行反应[7]. 但仍存在着产率不高或副产物多,后处理困难的问题

关键词: 对烷氧基苯甲醛, Wiliamson醚合成, Cannizzaro反应

Abstract: The p-alkoxybenzaldehydes are key intermediates for synthesis of liquid crystalline materials. This paper reports a new method for synthesizing p-alkoxybenzaldehydes from sodium p acylphenolate with n-alkyl bromide or chloride at certain temperature in EtOH. By using this method, some compounds have been obtained in good yield. Some synthetic routes are illustrated and evaluated.

Key words: p-alkoxybenzaldehydes, Willamson synthesis for ether, Cannizzaro reaction