中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (5): 1-4.

• 研究论文 •    下一篇

二乙胺液相催化羰化制备二乙基甲酰胺

刘兴泉, 吴玉塘, 贾朝霞, 于作龙   

  1. 中国科学院成都有机化学研究所 成都 610041
  • 收稿日期:1995-12-25 修回日期:1996-05-09 出版日期:1996-10-10 发布日期:1996-10-10
  • 基金资助:
    国家自然科学基金

Synthesis of Diethyl Formamide by Catalytic Carbonylation of Diethylamine in Liquid Phase

Liu Xingquan, Wu Yutang, Jia Zhaoxia, Yu Zuolong   

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
  • Received:1995-12-25 Revised:1996-05-09 Published:1996-10-10 Online:1996-10-10

PDF

415

被引次数

1

摘要： 考察了反应压力、催化剂、助催化剂和反应温度对二乙胺(DEA)液相羰基化合成二乙基甲酰胺(DEF)反应的影响,确定了量佳反应条件。结果表明,CO分压(PCO)对反应有明显影响,生成DEF的速率随P∞增大而增大;催化剂浓度对反应的速率影响较小,添加剂环氧丙烷(PO)对催化剂有较强的助催化作用,而且助催化作用随PO浓度的增加而增大,生成DEF的选择性随PO浓度的增加而降低,温度对反应也有明显的影响,确定最佳反应条件为:CO分压小于6.0MPa,反应温度为80℃至90℃,催化剂浓度不大于0.05mol/L,助催化剂PO浓度不大于4.0mol/L.此时选择性不小于96%.

关键词: 二乙胺, 催化羰化, 二乙基甲酰胺, 环氧丙烷, 助催化剂, 甲醇钠

Abstract: Effects of pressure, reaction temperature, concentration of catalyst and promoter on the synthesis of diethyl formamide(DEF) by catalytic carbonylation of diethylamine in liquid phase have been examined, and the optimal conditions of carbonylation have been determined. The experimental results have revealed that the partial pressure of carbon monoxide(Pco) has a marked effect on the reaction rate and the rate of DEF formation increases with the increase of the partial pressure of CO. The concentration of catalyst has a little influence on the reaction rate, but the carbonylation can not take place without catalyst. The propylene oxide(PO) additive has a strong promoter effect on sodium methoxide catalyst,and the promoter effect on the catalyst is directly proportional to the concentration of PO promoter.

Key words: diethylamine, catalytic carbonylation, diethyl formamide, propylene oxide, promoter, sodium methoxide

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