中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (4): 95-97.

• 研究简报 • 上一篇    下一篇

Nafion修饰玻碳电极对痕量维拉帕米的测定

冷宗周, 胡效亚, 杨功俊, 经卫   

  1. 扬州师范学院化学系 225002 扬州
  • 收稿日期:1992-10-10 修回日期:1993-03-30 出版日期:1993-08-10 发布日期:1993-08-10
  • 基金资助:
    江苏省教委自然科学基金

DETERMINATION OF TRACE VERAPAMIL ON NAFION-MODIFIED GLASSY CARBON ELECTRODE

Leng Zongzhou, Hu Xiaoya, Yang Gongjun, Jing Wei   

  1. Department of Chemistry, Yangzhou Teachers College, 225002 Yangzhou
  • Received:1992-10-10 Revised:1993-03-30 Published:1993-08-10 Online:1993-08-10

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摘要： 盐酸维拉帕米(verapamil VR+)是一种较重要的钙通道阻滞药,现行标准的分析法为非水滴定法,此外,尚有气相色谱法、高效液相色谱法和电极法等。Nafion修饰电极测定电活性阳离子药物如多巴胺(DA+)、去甲肾上腺素(NE+),异丙嗪(PM+)等已有报道。将DA+加到电解质溶液中,非电活性阳离子VR+与电活性的DA+在Nafion膜上竞争分配,使DA+的峰电流降低,峰电流的降低与VR+的浓度对数(在5×10-7～1×10-5mol/L范围内)呈良好的线性关系,以此测定VR+获得满意的结果。

关键词: 维拉帕米, Nafion修饰电极, 阴极溶出伏安法

Abstract: Verapamil is an electroinactive cationic drug. This paper describes the method for determination of trace verapamil on the Nafion-modified glassy carbon electrode. The peak current of dopamine is decreased when verapamil is added to an electrolyte solution containing electroactive dopamine. A good linear relationship was found between the extent of the decrease in the peak current and the logarithmic concentration of verapamil in the range of 5×10-7～1×10-5mol/L. The detection limit of the method was 2.5×10-7mol/L. The recovery was 96.2～105.7%, and the relative standard deviation was 3.2% (n=10).

Key words: verapamil, Nafion-modified electrode, cathodic stripping voltammetry

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