光诱导氧自由基与嘧啶碱基及其核苷反应的ESR研究

摘要/Abstract

摘要： 活性氧在破坏核酸结构,攻击其嘌呤碱基和嘧啶碱基,导致变异的出现和累积方面起重要作用^[1]。

Abstract: The technique of spin trapping and ESR method has been applied to study the reaction of superoxide radicals with pyrimidine bases and nucleoside in the presence of riboflavin and 2-methyl-2-nitrosopropane.The kinds of radicals produced were determined and the mechanism of the reaction was discussed. It is concluded that it is hydroxyl radicals rather than superoxide radicals that react with pyrimidine bases and nucleoside.

Key words: superoxide radical, hydroxyl radical, pyrimidine, nucleoside, spin trapping, ESR

王金富, 恽勤, 阎作琨. 光诱导氧自由基与嘧啶碱基及其核苷反应的ESR研究[J]. 应用化学, 1992, 0(6): 95-99.

Wang Jinfu, Yun Qin, Yan Zuokun. ESR STUDY ON REACTION OF LIGHT-INDUCED OXYGEN RADICALS WITH PYRIMIDINE BASES AND NUCLEOSIDES[J]. Chinese Journal of Applied Chemistry, 1992, 0(6): 95-99.

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光诱导氧自由基与嘧啶碱基及其核苷反应的ESR研究

ESR STUDY ON REACTION OF LIGHT-INDUCED OXYGEN RADICALS WITH PYRIMIDINE BASES AND NUCLEOSIDES

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