关键词: 铂配合物, NMR, 抗癌剂

Abstract: Some platinum complexes PtA₂X₂ have been synthesed (A ammonia, isopropylamine; X₂H₂ aspartic, thiodiglycollic and N-alkyl substituted iminodiaeetic acid). The complexes were characterized by ¹H NMR, ¹³C NMR and IR spectra. The results show that thiodiglycolic acid coordinates to Pt through S, O, O atoms, aspartic acid coordinates to Pt through N, O atoms. For N-alkyl substituted iminodiacetic acid two stable complexes were formed; at pH>5.5 this acid coordinates to Pt through N,O atoms and at pH<4 through N, O, O atoms.The stabilities of the complexes in aqueous solution were also investigated

Key words: platinum, complex, NMR, antitumor agent