中华医学超声杂志

应用化学 ›› 1990, Vol. 0 ›› Issue (4): 72-74.

• 研究简报 • 上一篇    下一篇

4-(N-烷基)胺甲基苯丙氨酸的合成

刘克良1, 何炳林1, 萧绍博2   

  1. 1. 南开大学高分子化学研究所 天津 300071;
    2. 天津计划生育研究所
  • 收稿日期:1989-08-21 修回日期:1990-01-12 出版日期:1990-08-10 发布日期:1990-08-10

SYNTHESIS OF 4-(N-SUBSTITUTED)AMINOMETHYL PHENYLALANINES

Liu Keliang1, He Binglin1, Xiao Shaobo2   

  1. 1. Institute of Polymer Chemistry, Nankai University, Tianjin 300071;
    2. Tianjin Municipal Research Institute for Family Palanning, Tianjin Medical College
  • Received:1989-08-21 Revised:1990-01-12 Published:1990-08-10 Online:1990-08-10

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摘要： 在生物活性肽研究中,通过在肽主链中引入特定结构的氨基酸,得到其活性类似物,可以使人们进一步认识肽结构与生物活性之间的关系,发展高活性、低副作用的肽类药物。蛋白氨基酸的结构都是一定的,不能满足研究工作的需要,所以需要设计合成特定结构的非蛋白氨基酸。

关键词: 4-(N-烷基)-胺甲基苯丙氨酸, 非蛋白氨基酸

Abstract: The new 4-(-N-substituted) aminomethyl phenylalanines are presented. Dialkylamine rea-cted with N-acetyl-4-chloromethyl phenylalanine ethyl ester to give phenylalanine derivativeswith basic side groups.After hydrolysis in hydrochloric acid and protection with Boc groupthe amino acids have been successfully used in solid phase peptide synthesis. This seriesamino acids combine basicity, aromaticity and hydrophilicity in the same molecule andhave different N-dialkyl groups in length, they can be used in systematic research onstructure-bioactivity relationships of peptides.

Key words: 4-(N-dialkyl)aminomethyl phenylanaline, nopnrotein amino acid, peptide

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