键合紫杉醇纳米胶束对H22肝癌小鼠的体内疗效评估

doi:10.3724/SP.J.1095.2011.00734

摘要/Abstract

摘要：

以H22肝癌的balb/c荷瘤小鼠为动物模型，考察了紫杉醇纳米胶束、紫杉醇注射液和生理盐水对小鼠肿瘤的抑制效果。紫杉醇注射液组、紫杉醇纳米胶束低剂量组和紫杉醇纳米胶束高剂量组在给药后10 d的肿瘤相对体积抑制率分别为22%、49%和67%，瘤重抑制率分别为29%、45%和47%；蛋白表达检测结果显示，紫杉醇纳米胶束组呈现p53的高表达和bcl-2的低表达，说明紫杉醇纳米胶束对小鼠H22肝癌的抑制作用强于紫杉醇注射液。

关键词: H22肝癌小鼠, 紫杉醇, 纳米胶束, 键合药

Abstract:

The anti-tumor effects of the polymer-paclitaxel conjugate micelles and free paclitaxel on H22 liver cancer bearing mice were evaluated. After 10 days drug administration, the tumor volume inhibition rates(VIR) of free paclitaxel group, polymer-paclitaxel conjugate micelles group at doses of 3 mg/kg, and the micelles group at doses of 6 mg/kg are 22%, 49%, and 67%, respectively. In addition, the tumor weight inhibition rates (WIR) are 29%, 45%, and 47%, respectively. Protein expression results show that paclitaxel micelles group has higher expression of p53 and lower expression of bcl-2. All these results indicate that the anti-tumor effect of polymer-paclitaxel conjugate micelles is stronger than free paclitaxel.

Key words: H22 liver cancer mice, Paclitaxel, nano-micelles, conjugate drug

中图分类号:

盛世厚, 于惠秋, 刘铜军, 柳时, 郑永辉, 胡秀丽, 宋祥福. 键合紫杉醇纳米胶束对H22肝癌小鼠的体内疗效评估[J]. 应用化学, 2011, 28(11): 1280-1285.

SHENG Shihou1, YU Huiqiu1, LIU Tongjun1*, LIU Shi2, ZHENG Yonghui2, HU Xiuli2, SONG Xiangfu3. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on H22 Liver Cancer Mice Models[J]. Chinese Journal of Applied Chemistry, 2011, 28(11): 1280-1285.

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键合紫杉醇纳米胶束对H22肝癌小鼠的体内疗效评估

Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on H22 Liver Cancer Mice Models

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