中华医学超声杂志

应用化学 ›› 2011, Vol. 28 ›› Issue (06): 624-628.DOI: 10.3724/SP.J.1095.2011.00512

• 研究论文 • 上一篇    下一篇

pH值、盐浓度敏感性两性聚电解质微球的合成及性质

高媛1,宁志刚1,宋春雷2,李洋1,张文德2,安会勇2,王丕新2*   

  1. (1.长春工业大学化学与生命科学学院 长春；
    2.中国科学院长春应用化学研究所生态环境高分子材料重点实验室 长春 130022)
  • 收稿日期:2010-09-02 修回日期:2010-11-14 出版日期:2011-06-10 发布日期:2011-06-10
  • 通讯作者: 王丕新，研究员; Tel/Fax:0431-85262629; E-mail:pxwang@ciac.jl.cn; 研究方向：水溶性高分子
  • 基金资助:
    吉林省与中国科学院科技合作资金项目(2009SYHZ0027)吉林省科技发展计划(20096023)资助项目

pH and Salt Concentration Sensitive Polyampholyte Microspheres: Synthesis and Properties

GAO Yuan1, NING Zhigang1, SONG Chunlei2, LI Yang1, ZHANG Wende2, AN Huiyong2, WANG Pixin1*   

  1. (1.Chemistry and Biology Science College,Changchun University of Technology,Changchun；
    2.Key Laboratory of Polymer Ecomaterials,Changchun Institute of
    Applied Chemistry,Chinese Academy of Sciences,Changchun 130022)
  • Received:2010-09-02 Revised:2010-11-14 Published:2011-06-10 Online:2011-06-10

PDF

2379

被引次数

2

摘要：

以丙烯酰胺(AM)、丙烯酰氧乙基三甲基氯化铵(DAC)和甲基丙烯酸(MAA)为单体，在乙醇介质中制备出对pH值、盐浓度双敏感的两性聚电解质微球。 采用透射电子显微镜(TEM)和红外光谱(IR)方法对其形貌和结构进行了表征。 研究了聚电解质微球在不同pH值溶液及NaCl、CaCl2盐溶液中粒径的变化情况。研究结果表明，第二步中反应制备的微球粒径为1 177 nm，多分散指数(PDI)为0.181；相比第一步反应制备的微球(d=764 nm；PDI=0.069)其粒径明显增大，PDI数值略有增加。当溶液pH＜4.3时，微球的粒径随溶液pH值的减小而逐渐增加；当pH＞4.3时，微球的粒径随溶液pH值的变大逐渐增加；pH=4.3时，微球的粒径具有最小值。盐溶液的pH值接近等电点时，在单价态NaCl溶液中，两性聚电解质微球表现出典型反聚电解质效应；而在多价态CaCl2溶液中，其粒径先增长再逐渐下降。

关键词: pH响应性, 盐浓度响应性, 两性聚电解质, 反聚电解质效应

Abstract:

Polyampholyte microspheres with pH and salt concentration sensitive behaviors were prepared by acrylamide(AM), acryloylxyethyl trimethyl ammonium chloride(DAC) and methacrylic acid(MAA) in ethanol. The shape and conformation of microspheres were determined by transmission electron microscope and infrared spectroscopy, respectively. Meanwhile, the change behavior of the microsphere diameter in various pH solutions and in NaCl and CaCl2 salt solutions was investigated. The results indicated that the diameter of microspheres was 1 177 nm， and polydispersity index(PDI) value was 0.181 at the second step, which were greater than those(d=764 nm； PDI=0.069) at the first step. The diameter of microspheres increased with decreasing pH when the pH was lower than pH=4.3. Whereas when the pH was higher than 4.3, the diameter increased with increasing pH, and a minimum diameter was obtained when the pH was 4.3. At the isoelectric point, the dispersion exhibited a typical antipolyelectrolyte effect in univalent NaCl salt solution. However, in multivalent CaCl2 salt solution, the diameter of microspheres first increased and then decreased.

Key words: pH-responsive, Salt concentration responsive, Polyampholyte, Antipolyelectrolyte effect

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