中华医学超声杂志

应用化学 ›› 2011, Vol. 28 ›› Issue (03): 254-257.DOI: 10.3724/SP.J.1095.2011.00151

• 研究论文 • 上一篇    下一篇

洗滤-萃取法去除ATRP法制备PMMA-b-PLLA-b-PMMA嵌段聚合物中的Cu离子

仲玉,沈珺,魏荣卿,刘晓宁*   

  1. (南京工业大学生物与制药工程学院 南京 210009)
  • 收稿日期:2010-03-15 修回日期:2010-08-23 出版日期:2011-03-10 发布日期:2011-03-10
  • 通讯作者: 刘晓宁，教授; Tel:025-83587347; Fax:025-83532182; E-mail:xiaoningliu@163.com; 研究方向：高分子材料的合成；高效色谱分离材料的合成及应用
  • 基金资助:
    国家高技术研究发展计划（“863”计划）（2007AA02Z200，2007AA06A402）资助项目

Removal of Cu-ion in block copolymer of PMMA-PLLA-PMMA prepared via ATRP by washing-extraction method

ZHONG Yu, SHEN Jun, WEI Rongqing, LIU Xiaoning*   

  1. (College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009)
  • Received:2010-03-15 Revised:2010-08-23 Published:2011-03-10 Online:2011-03-10

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摘要：

采用洗滤-萃取法去除原子转移自由基聚合法(ATRP)制备的聚甲基丙烯酸甲酯-聚L-乳酸-聚甲基丙烯酸甲酯(PMMA-b-PLLA-b-PMMA)嵌段共聚物中残留金属Cu离子。 结果表明，采用二氯甲烷(DCM)溶解共聚物，用水或酸水洗滤-萃取，当重复洗滤萃取5次后，Cu离子的去除率能达到99%，所得嵌段共聚物的收率高于80%。 与过Al2O3层析柱或溶剂溶解沉淀方法相比，洗滤-萃取法操作简单、可节省大量的有机溶剂，具有工业化前景。

关键词: 原子转移自由基聚合, 聚甲基丙烯酸甲酯-聚L-乳酸-聚甲基丙烯酸甲酯, Cu离子的去除, 洗滤-萃取法

Abstract:

This paper developed a washing-extraction method to remove the residual Cu-ion from the triblock copolymer of poly(methyl methacrylate)-b-poly(L-lactic acid)-b-poly(methyl methacrylate)(PMMA-b-PLLA-b-PMMA) prepared via atom transfer radical polymerization(ATRP). The result is that, when taking dichloromethane(DCM) as the solvent and water or acid as the extractant, the rate of removing Cu-ion can reach as much as 99% and the yield of the block copolymerization was more than 80% followed by washing and extracting 5 times. Compared with other methods, the washing-extraction method can not only save lots of organic solvent, but is also simple and effective. In addition, the washing-extraction method is a green technology, which might be used in the industry.

Key words: atom transfer radical polymerization, PMMA-b-PLLA-b-PMMA, removal of Cu, washing-extraction method

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