中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (05): 563-566.DOI: 10.3724/SP.J.1095.2010.90448

• 研究论文 • 上一篇    下一篇

对称四甲基取代六元瓜环对醋酸地塞米松的增溶作用

李国平*,俞芳琴,林金鹤,陈银枝   

  1. (漳州师范学院化学与环境科学系 漳州 363000)
  • 收稿日期:2009-07-09 修回日期:2009-09-21 出版日期:2010-05-10 发布日期:2010-05-10
  • 通讯作者: 李国平，男，讲师; E-mail:liguoping-2003@163.com; 研究方向：大环与超分子化学
  • 基金资助:
    教育厅科技（JA08157）校教师科研启动经费资助项目

The Solubility Improvement of tetramethyl substituted Cucurbit[6]uril on Dexamethasone Acetate

LI Guo-Ping*, YU Fang-Qin, LIN Jin-He, CHEN Yin-Zhi   

  1. (Department of Chemistry and Environmental Science,Zhangzhou Normal University,Zhangzhou 363000)
  • Received:2009-07-09 Revised:2009-09-21 Published:2010-05-10 Online:2010-05-10

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1442

被引次数

13 | 1

摘要：

利用微孔滤膜分离方法研究了对称四甲基取代六元瓜环（TMeQ[6]）对醋酸地塞米松的增溶作用，并利用差热分析法(DTA)分析TMeQ[6]和醋酸地塞米松的包结物。 结果表明，TMeQ[6]对醋酸地塞米松有一定的增溶作用，随TMeQ[6]浓度增大，醋酸地塞米松的溶解度呈增大趋势，当TMeQ[6]浓度从0.04 mmol/L提高至0.28 mmol/L增溶倍数可达4~17倍；当温度从10 ℃升至70 ℃，增溶倍数先下降然后趋于稳定。 同时，还利用共溶剂法制备了TMeQ[6]与醋酸地塞米松的固体包结物，并对其主客体作用进行了DTA研究。

关键词: 对称四甲基取代六元瓜, 醋酸地塞米松, 增溶, 包结物

Abstract:

The solubility improvement of dexamethasone acetate by tetramethyl substituted cucurbit[6]urils(TMeQ[6]) was studied with the micro porous filter membrane separation technique, and the solid inclusion complex of TMeQ[6] and dexamethasone acetate was analyzed with the method of DTA.The results show that TMeQ[6] was able to increase the solubility of dexamethasone acetate, and the solubilization improvement could reach 4~17fold when the concentration of TMeQ[6] increased from 0.04 to 0.28 mmol/L. While the temperature increased from 10 ℃ to 70 ℃, the solubilization decreased in the range of 10~30 ℃, and then leveled off in the range of 40~70 ℃. At the same time, the solid inclusion complex of dexamethasone acetate with TMeQ[6] was prepared through cosolvent method, and its hostguest interaction was studied by DTA.

Key words: TMeQ[6], dexamethasoneacetate, solubilityimprovement, inclusioncomplex

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