中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (03): 328-332.DOI: 10.3724/SP.J.1095.2010.90205

• 研究论文 • 上一篇    下一篇

没食子酸丙酯Fe(Ⅲ)、Cr(Ⅲ)、Cu(Ⅱ)配合物的合成、表征及模拟超氧化物歧化酶

伍林*,严敏,王建国,官章伟,夏志林,秦晓蓉,易德莲   

  1. (武汉科技大学应用化学研究所 武汉 430081)
  • 收稿日期:2009-03-27 修回日期:2009-06-24 出版日期:2010-03-10 发布日期:2010-03-10
  • 通讯作者: 伍林，男，教授，博士生导师; E-mail:wulin65@163.com; 研究方向：有机合成及功能高分子材料
  • 基金资助:
    湖北省教育厅科研重点基金资助项目(D20081102)

Synthesis, Characterization and Simulation of SOD of M(M:Fe(Ⅲ)，Cr(Ⅲ)，Cu(Ⅱ)) Propyl Gallate Complexes

WU Lin*, YAN Min, WANG Jian-Guo, GUAN Zhang-Wei, XIA Zhi-Lin, QIN Xiao-Rong, YI De-Lian   

  1. (Applied Chemistry Research Institute,Wuhan University of Science and Technology,Wuhan  430081)
  • Received:2009-03-27 Revised:2009-06-24 Published:2010-03-10 Online:2010-03-10

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被引次数

1 | 1

摘要：

研究了没食子酸丙酯在水溶液中分别与Fe3+、Cr3+、Cu2+生成没食子酸丙酯-铁(PG-Fe)、没食子酸丙酯-铬(PG-Cr)、没食子酸丙酯-铜(PG-Cu)这3种金属配合物(PG-M)的反应。 通过紫外光谱、核磁共振、红外光谱、质谱、元素分析、摩尔电导率和循环伏安法等测试技术对3种金属配合物进行了表征。 确定3种金属配合物的分子式分别为[C10H10O5]2Fe·H2O、[C10H10O5]3Cr·2H2O、[C10H10O5]2Cu·2H2O。 红外光谱分析表明，中心金属原子与酚羟基发生配位，形成Ar—O—M键。 电化学数据显示，PG-M的抗氧化性优于PG配体，且PG-Cu＞PG-Cr＞PG-Fe。 用改进的核黄素光还原NBT法检测了3种金属配合物的模拟超氧化物歧化酶(SOD)活性。 结果表明，3种金属配合物均有一定的催化歧化超氧阴离子自由基(O-2·)活性，均可被称作超氧化物歧化酶活性中心的模拟配合物。

关键词: 没食子酸丙酯，配合物，循环伏安法，超氧化物歧化酶(SOD)

Abstract:

The interactions of Fe3+, Cr3+, Cu2+ with propyl gallate(PG) in water were studied. The solid complexes of PG-Fe, PG-Cr, PG-Cu were characterized by UV-Vis, 1H NMR, IR, MS, elemental analysis, molar conductance and cyclic voltammetry. The results support the formation of the complexes with the formulae [C10H10O5]2Fe·H2O, [C10H10O5]3Cr·2H2O and [C10H10O5]2Cu·2H2O for investigated metal cations. The IR spectra show that the phenol hydroxyl group was coordinated to the metal center to form the Ph—O—M bond. The electrochemical data suggest that the metal complexes were more effective antioxidants than PG ligand, and the antioxidative property follows the order:PG-Cu＞PG-Cr＞PG-Fe. The superoxide dismutase(SOD) like activity of the metal complexes was measured by means of a reduction of NBT by VB2. The results indicate that the three metal complexes could catalyze the disproportionation of the superoxide anion free radical (O-2·), and could be used as the active center model complexes of SOD.

Key words: propyl gallate,complex,cyclic voltammetry,SOD

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