应用化学 ›› 2010, Vol. 27 ›› Issue (02): 125-131.DOI: 10.3724/SP.J.1095.2010.90384

• 综合评述 •    下一篇

DNA折纸术研究进展

付衍明1,3,张钊2,李璨2,师咏勇2,阎秀峰1,樊春海3*   

  1. (1.东北林业大学生命科学学院 哈尔滨;2.上海交通大学Bio-X中心 上海;
    3.中国科学院上海应用物理研究所 上海 201800)
  • 收稿日期:2009-06-08 修回日期:2009-07-31 出版日期:2010-02-10 发布日期:2010-02-10
  • 通讯作者: 樊春海,男,博士,研究员; E-mail:fchh@sinap.ac.cn; 研究方向:生物传感器与DNA纳米技术
  • 基金资助:
    国家自然科学基金资助项目(60537030)

Recent Progress in DNA origami

FU Yan-Ming1,3, ZHANG Zhao2, LI Can2, SHI Yong-Yong2, YAN Xiu-Feng1, FAN Chun-Hai3*   

  1. (1.Northeast Forestry University,Harbin;
    2.Bio-X Center,Shanghai Jiao Tong University,Shanghai;
    3.Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800)
  • Received:2009-06-08 Revised:2009-07-31 Published:2010-02-10 Online:2010-02-10

摘要:

DNA折纸术是近年来提出的一种全新的DNA自组装的方法,是DNA纳米技术与DNA自组装领域的一个重大进展。与传统的DNA自组装技术不同,DNA折纸术通过将一条长的DNA单链(通常为基因组DNA)与一系列经过设计的短DNA片段进行碱基互补,能够可控地构造出高度复杂的纳米图案或结构,在新兴的纳米领域中具有广泛的潜在应用。本文在介绍DNA折纸术相关原理的基础上,就DNA折纸术的起源、发展及其在DNA芯片、纳米元件与材料等领域的潜在应用进行了概述,探讨了DNA折纸术未来可能的发展方向。

关键词: DNA自组装,DNA折纸术,纳米技术

Abstract:

DNA origami is a new DNA self-assembly method raised recently, and it is a major innovation in the field of DNA nanotechnology and self-assembly. Compared to the traditional DNA self-assembly, DNA origami uses a long single-stranded genomic DNA with a series of short complementary single-strands DNA, and it can construct more complex and more controllable nanopatterns or structures, with a wide range of potential applications in the emerging field of nanotechnology. In this paper, we briefly introduced the principles of DNA origami, then reviewed the origin and development of DNA origami and its potential applications in the field of DNA chip, nanocomponents and nanomaterials. At the end we discussed the future directions of development.

Key words: DNA self-assembly,DNA origami,Nanotechnology

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