22-降-豆甾-22-含氮化合物的合成及抗肿瘤活性

杨雷^a, 范良华^b, 赵丹丹^a, 戚斌斌^a, 甘春芳^a, 崔建国^a, 黄燕敏^a,^*

Synthesis and Antiproliferative Activity of 22-Abeo-stigmast-22-nitrogen-containing Compounds

YANG Lei^a, FAN Lianghua^b, ZHAO Dandan^a, QI Binbin^a, GAN Chunfang^a, CUI Jian'guo^a, HUANG Yanmin^a,^*

Scheme 1 Synthesis of 22-abeo-stigmast-22-nitrogen-containing compounds Reagents and conditions:a.Ac 2 OPyridiner.t., 24 h; b.Br 2 , PhI, hexane; c.1O 3 CH 2 Cl 2 , -78 ℃;2ZnAcOH, 12 h; d.NH 2 NHCONH 2 AcOH, EtOH for compound 5; e.NH 2 NHCSNH 2 AcOH, EtOHfor compound 6; f. m KOH#cod#x02236; m MeOH=5#cod#x02236;95