Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives

doi:10.11944/j.issn.1000-0518.2015.03.140197

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (3): 278-283.DOI: 10.11944/j.issn.1000-0518.2015.03.140197

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Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives

XU Zhaohui^*, LIN Chunhua, LIAO Weilin

Chemistry and Chemical Engineering Department,Jiangxi Normal University,Nanchang 330027,China

Received:2014-06-05 Accepted:2014-07-21 Published:2015-03-02 Online:2015-03-02
Contact: Zhaohui XU
Supported by:
Supported by the National Science and Technology Project(No.2001BA323C), the Graduate Innovation Foundation of Jiangxi Province(No.YC10A51)

Abstract

Abstract:

Ten 5-[(indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized by the three component condensation reaction of indole, aldehyde and 2,2-dimethyl-1,3-dioxane-4,6-dione using iodine as the catalyst. The results indicates that the yields range from 71.4% to 97.3% at 30 ℃ for 60~90 min using 5% molar fraction of iodine. Furthermore, a mechanism for the reaction catalyzed by iodine is proposed.

Key words: dimethyl-dioxane-dione, iodine, aldehydes, three component condensation reaction

CLC Number:

XU Zhaohui, LIN Chunhua, LIAO Weilin. Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives[J]. Chinese Journal of Applied Chemistry, 2015, 32(3): 278-283.

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Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives

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