基于水杨酰腙配体的二丁基锡配合物的合成、晶体结构、热稳定性及与DNA相互作用

doi:10.11944/j.issn.1000-0518.2015.05.140324

摘要/Abstract

摘要：

2-羰基丙酸水杨酰腙与二丁基氧化锡反应, 合成了二丁基锡2-羰基丙酸水杨酰腙配合物, 经元素分析、¹H NMR、¹³C NMR、IR、UV-Vis和X射线单晶衍射等技术手段表征分子结构, 结构分析表明, 该配合物晶体属四方晶系, 锡与配位原子形成变形五角双锥构型的双核有机锡配合物, 分子以Sn₂O₂四元环为中心对称。热分析结果表明, 在空气氛下, 配合物在103 ℃以下可稳定存在; 研究了配合物在近生理条件下与DNA的相互作用, 用紫外光谱、荧光光谱法及粘度法研究了配合物与鲱鱼精DNA的相互作用, 结果表明, 配合物与鲱鱼精DNA作用方式为插入结合。

关键词: 有机锡配合物, 合成, 晶体结构, 热稳定性, DNA

Abstract:

2-(Salicyloylhydrazone)propionic acid dibutytin complex was synthesized via the reaction of 2-(salicyloylhydrazone)propionic acid with dibutyltin oxide. The complex was characterized by IR, ¹H NMR, ¹³C NMR spectroscopy, and elemental analysis. The crystal structure was determined to be a tetragonal system by single crystal X-ray diffraction. The crystal structure of the complex belongs to a centrosymmetric structure mode with a four-member central Sn₂O₂ unit, in which the central Sn atom is seven-coordinated in a distorted pentagonal pyramid configuration. The complex is stable below 103 ℃ according to thermal analysis. The interaction between the complex and Herring sperm DNA was studied by UV spectroscopy, ethidium bromide(EB) fluorescent probe and viscosity, and the results suggest the intercalation interaction between the complex and Herring sperm DNA.

Key words: organotin complex, synthesis, crystal structure, thermal stability, DNA

中图分类号:

郑建华, 刘俊, 肖尧, 戴玲林, 李海洋, 谭宇星, 冯泳兰, 蒋伍玖, 庾江喜, 邝代治. 基于水杨酰腙配体的二丁基锡配合物的合成、晶体结构、热稳定性及与DNA相互作用[J]. 应用化学, 2015, 32(5): 562-569.

ZHENG Jianhua, LIU Jun, XIAO Yao, DAI Linglin, LI Haiyang, TAN Yuxing, FENG Yonglan, JIANG Wujiu, YU Jiangxi, KUANG Daizhi. Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 562-569.

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