Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan

doi:10.3724/SP.J.1095.2014.40072

Chinese Journal of Applied Chemistry

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Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan

TAN Funeng^1*, HE Yuanyuan², SUI Weiping³

(1.Chemical and Engineering Institute,Wenshan University,Wenshan 663000,China;
2.Wenshan City Agricultural Enviroment Protection and Monitoring Station,Wenshan 663000,China;
3.College of Chemistry and Chemical Engineering,University of Ji′nan,Ji′nan 250022,China)

Received:2014-03-11 Revised:2014-05-15 Published:2014-11-08 Online:2014-11-08
Contact: Tan Funeng

Abstract

Abstract: (2-Hydroxy-3-butoxy)propyl hydroxypropyl chitosan (2-H-3-B-P-HPCS) was synthesized to prepare 2-H-3-B-P-HPCS/polyethylene glycol (2-H-3-B-P-HPCS/PEG) interpenetrating polymer network(IPN) hydrogels. The factors that could influence swelling properties of 2-H-3-B-P-HPCS/PEG IPN hydrogels were studied, such as concentration of 2-H-3-B-P-HPCS, reaction temperature， amount of PEG and glutaral. The 2-H-3-B-P-HPCS/PEG IPN hydrogels were investigated by SEM and IR. Aciclovir as a model drug was used to study the release performance. The results show that 2-H-3-B-P-HPCS/PEG IPN hydrogels have good swelling property, pH sensibility and drug releasing ability and can be used for a new drug carrier.

Key words: (hydroxy-butoxy)propyl-hydroxypropyl chitosan, polyethylene glycol, hydrogel, drug release

CLC Number:

O635

TAN Funeng1*, HE Yuanyuan2, SUI Weiping3. Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.40072.

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Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan

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